Operational Tolerance in Nonvascularized Transplant Models Induced by AR-C117977, a Monocarboxylate Transporter Inhibitor

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	Operational Tolerance in Nonvascularized Transplant Models Induced by AR-C117977, a Monocarboxylate Transporter Inhibitor
	Pahlman, Clara ; Malm, Helene ; Qi, Zhongquan ; Veress, Bela ; Ferguson, Douglas ; Bundick, Robert ; Murray, Clare ; Donald, David ; Ekberg, Henrik ; Qi ZQ(齐忠权)
刊名	http://dx.doi.org/10.1097/TP.0b013e318186b978
	2008-10-27
关键词	ALLOGRAFT RAT ISLETS MCT1
英文摘要	AR-C117977, a monocarboxylate transporter inhibitor, reduces immune responses both in vitro and in vivo, maintains long-term graft survival, and induces operational tolerance. To evaluate the immunosuppressive limitations of AR-C117977, this study was performed in nonvascularized transplant models noted for their refractive response to standard immunosuppressive agents. Rat skin was transplanted from DA(RT1(avl)) into PVG(RT1(c)) and the reverse. Mouse islet allotransplantation was performed with BALB/c H2(d) donors and C57Bl/6J H2(b) recipients. In the skin graft model, AR-C117977 monotherapy was associated with long-term skin graft survival in one rat strain combination. AR-C117977 and cyclosporine A (CsA) in combination resulted in significant prolongation of graft survival in both rat strains. CsA monotherapy did not prevent acute rejection in either strain. Islet allograft survival was moderately prolonged with CsA or AR-C117977. AR-C117977 is an efficient immunosuppressive drug in stringent rodent transplant models and further studies are warranted.
语种	英语
出版者	TRANSPLANTATION
内容类型	期刊论文
源URL	[http://dspace.xmu.edu.cn/handle/2288/93374]
专题	医学院－已发表论文
推荐引用方式 GB/T 7714	Pahlman, Clara,Malm, Helene,Qi, Zhongquan,et al. Operational Tolerance in Nonvascularized Transplant Models Induced by AR-C117977, a Monocarboxylate Transporter Inhibitor[J]. http://dx.doi.org/10.1097/TP.0b013e318186b978,2008.
APA	Pahlman, Clara.,Malm, Helene.,Qi, Zhongquan.,Veress, Bela.,Ferguson, Douglas.,...&齐忠权.(2008).Operational Tolerance in Nonvascularized Transplant Models Induced by AR-C117977, a Monocarboxylate Transporter Inhibitor.http://dx.doi.org/10.1097/TP.0b013e318186b978.
MLA	Pahlman, Clara,et al."Operational Tolerance in Nonvascularized Transplant Models Induced by AR-C117977, a Monocarboxylate Transporter Inhibitor".http://dx.doi.org/10.1097/TP.0b013e318186b978 (2008).