Parthenolide induces apoptosis and lytic cytotoxicity in Epstein-Barr virus-positive Burkitt lymphoma

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	Parthenolide induces apoptosis and lytic cytotoxicity in Epstein-Barr virus-positive Burkitt lymphoma
	Li, Yuan ; Zhang, Yongli ; Fu, Mingming ; Yao, Qin ; Zhuo, Huiqin ; Lu, Quanyi ; Niu, Xiaoqing ; Zhang, Peng ; Pei, Yihua ; Zhang, Kejie ; Lu QY(鹿全意) ; Niu XQ(牛小青) ; Zhang P(张鹏) ; Zhang KJ(张可杰)
刊名	http://dx.doi.org/10.3892/mmr.2012.959
	2012-09
关键词	NF-KAPPA-B TUMOR-CELLS PROTEIN CANCER REPLICATION INHIBITION PATHWAY DEATH CHEMOTHERAPY MALIGNANCIES
英文摘要	Fujian Provincial Department of Science and Technology [2009-CXB-57, 2011J01252]; Bureau of Science and Technology of Xiamen, China [3502Z20094012]; Burkitt lymphoma (BL) has been reported to be strongly associated with Epstein-Barr virus (EBV) infection. The fact that EBV is generally present in cancer cells but rarely found in healthy cells represents an opportunity for targeted cancer therapy. One approach is to activate the lytic replication cycle of the latent EBV. Nuclear factor (NF)-kappa B is thought to play an essential role in EBV lytic infection. Elevated NF-kappa B levels inhibit EBV lytic replication. Parthenolide (PN) is a sesquiterpene lactone found in medicinal plants, particularly in feverfew (Tanacetum parthenium). The aim of the present study was to analyze the effect of PN on the survival of Raji EBV-positive lymphoma cells. Raji cells were treated with 0,4 or 6 mu mol/l PN for 48 h. MTT assay and western blot analysis were performed to evaluate the findings. Results showd that PN suppressed the growth of the EBV-positive BL cell line, Raji, and activated the transcription of BZLFI and BRLFI by inhibiting NF-kappa B activity. Most notably, when PN was used in combination with ganciclovir (GCV), the cytotoxic effect of PN was amplified. These data suggest that the induction of lytic EBV infection with PN in combination with GCV may be a viral-targeted therapy for EBV-associated BL.
语种	英语
出版者	MOL MED REP
内容类型	期刊论文
源URL	[http://dspace.xmu.edu.cn/handle/2288/93331]
专题	医学院－已发表论文
推荐引用方式 GB/T 7714	Li, Yuan,Zhang, Yongli,Fu, Mingming,et al. Parthenolide induces apoptosis and lytic cytotoxicity in Epstein-Barr virus-positive Burkitt lymphoma[J]. http://dx.doi.org/10.3892/mmr.2012.959,2012.
APA	Li, Yuan.,Zhang, Yongli.,Fu, Mingming.,Yao, Qin.,Zhuo, Huiqin.,...&张可杰.(2012).Parthenolide induces apoptosis and lytic cytotoxicity in Epstein-Barr virus-positive Burkitt lymphoma.http://dx.doi.org/10.3892/mmr.2012.959.
MLA	Li, Yuan,et al."Parthenolide induces apoptosis and lytic cytotoxicity in Epstein-Barr virus-positive Burkitt lymphoma".http://dx.doi.org/10.3892/mmr.2012.959 (2012).