Edaravone for acute ischaemic stroke

CORC > 厦门大学 > 医学院－已发表论文

	Edaravone for acute ischaemic stroke
	Feng, Shejun ; Yang, Qingwei ; Liu, Ming ; Li, Weizheng ; Yuan, Wenming ; Zhang, Shihong ; Wu, Bo ; Li, Juntao ; Yang QW(阳清伟) ; Liu M(刘明)
刊名	http://dx.doi.org/10.1002/14651858.CD007230.pub2
	2011
关键词	FREE-RADICAL SCAVENGER CEREBRAL-ISCHEMIA BRAIN INFARCTION DOUBLE-BLIND MCI-186 TRIALS MULTICENTER EFFICACY THERAPY EDEMA
英文摘要	Chinese Cochrane Centre, China; Background Neuroprotection is a promising therapeutic strategy for the treatment of acute ischaemic stroke. Edaravone is a neuroprotective agent that has been widely used in China, and several studies have suggested that it may be beneficial in acute ischaemic stroke. Objectives To assess the efficacy and safety of edaravone for acute ischaemic stroke. Search methods We searched the Cochrane Stroke Group Trials Register (November 2010) and the Chinese Stroke Trials Register (November 2010). In addition, we searched the Cochrane Central Register of Controlled Trials (CENTRAL) (The Cochrane Library 2010, Issue 4), MEDLINE (1950 to November 2010), EMBASE (1980 to November 2010), China National Knowledge Infrastructure (1979 to November 2010), Chinese Biomedical Database (1979 to November 2010), Chinese Evidence-Based Medicine Database (November 2010) and Chinese Science and Technology Journals Database (1980 to November 2010). In an attempt to identify further published, unpublished and ongoing trials we searched reference lists and clinical trials and research registers, and contacted a pharmaceutical company, researchers and study authors. Selection criteria We included randomised controlled trials comparing edaravone with placebo or no intervention in patients with acute ischaemic stroke. Data collection and analysis Two review authors selected trials for inclusion, assessed trial quality and independently extracted the data. Main results We included three trials, involving 496 participants, and defined four trials as waiting assessment. All three included trials were of edaravone plus another treatment compared with the other treatment alone. The dose of edaravone injections in the three trials was the same at 60 mg per day. The course of treatment in all three trials is 14 days. None of the included trials reported the pre-specified primary outcome of death or dependency defined using the modified Rankin scale during the follow-up period. The three trials evaluated the effect of edaravone at different times and using different methods. All three trials reported adverse events; there were no differences between the treatment group and the control group. Overall, edaravone appeared to increase the proportion of participants with marked neurological improvement compared with the control group, and the difference was significant (risk ratio (RR) 1.99, 95% confidence interval (CI) 1.60 to 2.49). Authors' conclusions The risk of bias in the included trials was moderate and the sample was small. Hence, although the data in this review show an effective treatment trend of edaravone for acute ischaemic stroke, further large, high-quality trials are required to confirm this trend.
语种	英语
出版者	COCHRANE DB SYST REV
内容类型	期刊论文
源URL	[http://dspace.xmu.edu.cn/handle/2288/93319]
专题	医学院－已发表论文
推荐引用方式 GB/T 7714	Feng, Shejun,Yang, Qingwei,Liu, Ming,et al. Edaravone for acute ischaemic stroke[J]. http://dx.doi.org/10.1002/14651858.CD007230.pub2,2011.
APA	Feng, Shejun.,Yang, Qingwei.,Liu, Ming.,Li, Weizheng.,Yuan, Wenming.,...&刘明.(2011).Edaravone for acute ischaemic stroke.http://dx.doi.org/10.1002/14651858.CD007230.pub2.
MLA	Feng, Shejun,et al."Edaravone for acute ischaemic stroke".http://dx.doi.org/10.1002/14651858.CD007230.pub2 (2011).