Combination of monoclonal antibodies with DST inhibits accelerated rejection mediated by memory T cells to induce long-lived heart allograft acceptance in mice

CORC > 厦门大学 > 医学院－已发表论文

	Combination of monoclonal antibodies with DST inhibits accelerated rejection mediated by memory T cells to induce long-lived heart allograft acceptance in mice
	Shao, Wei ; Chen, Jibing ; Dai, Helong ; Peng, Yuanzheng ; Wang, Feng ; Xia, Junjie ; Thorlacius, Henrik ; Zhu, Qi ; Qi, Zhongquan ; Chen JB(陈继冰)
刊名	http://dx.doi.org/10.1016/j.imlet.2011.03.009
	2011-08-30
关键词	DONOR-SPECIFIC TRANSFUSION ALLOANTIGEN-PRIMED MICE TRANSPLANTATION TOLERANCE IN-VIVO CD4(+) ACTIVATION COSTIMULATION MECHANISMS BLOCKADE BARRIER
英文摘要	Medical College of Xiamen University; Donor-reactive memory T cells mediated accelerated rejection is known as a barrier to the survival of transplanted organs. We investigated the combination of different monoclonal antibodies (mAbs) and donor-specific transfusion (DST) in memory T cells-based adoptive mice model. In the presence of donor reactive memory T cells, the mean survival time (MST) of grafts in the anti-CD40L/LFA-1/DST group was 49.8 d. Adding anti-CD44/CD70 mAbs to anti-CD40L/LFA-1/DST treatment. The MST was more than 100 d (MST > 100 d). Compared with anti-CD40L/LFA-1/DST group, anti-CD40L/LFA-1/CD44/CD70/DST group notably reduced the expansion of memory T cells, enhanced the proportion of CD4(+)Foxp3(+) regulatory T cells (Tregs) and suppressed donor-specific responses. Our data suggest that anti-CD40L/LFA--1/CD44/CD70 mAbs and DST can synergistically inhibit accelerated rejection mediated by memory T cells to induce long-lived heart allograft acceptance in mice. (C) 2011 Elsevier B.V. All rights reserved.
语种	英语
出版者	IMMUNOL LETT
内容类型	期刊论文
源URL	[http://dspace.xmu.edu.cn/handle/2288/93276]
专题	医学院－已发表论文
推荐引用方式 GB/T 7714	Shao, Wei,Chen, Jibing,Dai, Helong,et al. Combination of monoclonal antibodies with DST inhibits accelerated rejection mediated by memory T cells to induce long-lived heart allograft acceptance in mice[J]. http://dx.doi.org/10.1016/j.imlet.2011.03.009,2011.
APA	Shao, Wei.,Chen, Jibing.,Dai, Helong.,Peng, Yuanzheng.,Wang, Feng.,...&陈继冰.(2011).Combination of monoclonal antibodies with DST inhibits accelerated rejection mediated by memory T cells to induce long-lived heart allograft acceptance in mice.http://dx.doi.org/10.1016/j.imlet.2011.03.009.
MLA	Shao, Wei,et al."Combination of monoclonal antibodies with DST inhibits accelerated rejection mediated by memory T cells to induce long-lived heart allograft acceptance in mice".http://dx.doi.org/10.1016/j.imlet.2011.03.009 (2011).