Production and Radioprotective Effects of Pyrroloquinoline Quinone

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	Production and Radioprotective Effects of Pyrroloquinoline Quinone
	Xiong, Xiang-Hua ; Zhao, Yan ; Ge, Xin ; Yuan, Shou-Jun ; Wang, Jian-Hua ; Zhi, Jing-Juan ; Yang, Yan-Xin ; Du, Bao-Hua ; Guo, Wan-Jun ; Wang, Shan-Shan ; Yang, De-Xuan ; Zhang, Wei-Cai ; Zhao Y(赵岩)
刊名	http://dx.doi.org/10.3390/ijms12128913
	2011-12
关键词	STRAND BREAK REPAIR ESCHERICHIA-COLI ACINETOBACTER-CALCOACETICUS DEINOCOCCUS-RADIODURANS GLUCOSE-DEHYDROGENASE OXIDATIVE STRESS PROTEIN-KINASE PQQ BACTERIA QUINOPROTEIN
英文摘要	National Programs for High Technology Research and Development of China [2006AA020303]; National Key Technology RD Program [2007BAI46B01]; Pyrroloquinoline quinone (PQQ) was produced by fermentation of the Methylovorus sp. MP688 strain and purified by ion-exchange chromatography, crystallization and recrystallization. The yield of PQQ reached approximately 125 mg/L and highly pure PQQ was obtained. To determine the optimum dose of PQQ for radioprotection, three doses (2 mg/kg, 4 mg/kg, 8 mg/kg) of PQQ were orally administrated to the experimental animals subjected to a lethal dose of 8.0 Gy in survival test. Survival of mice in the irradiation + PQQ ( 4 mg/kg) group was found to be significantly higher in comparison with the irradiation and irradiation + nilestriol (10 mg/kg) groups. The numbers of hematocytes and bone marrow cells were measured for 21 days after sublethal 4 Gy gamma-ray irradiation with per os of 4 mg/kg of PQQ. The recovery of white blood cells, reticulocytes and bone marrow cells in the irradiation + PQQ group was faster than that in the irradiation group. Furthermore, the recovery of bone marrow cell in the irradiation + PQQ group was superior to that in irradiation + nilestriol group. Our results clearly indicate favourable effects on survival under higher lethal radiation doses and the ability of pyrroloquinoline quinine to enhance haemopoietic recovery after sublethal radiation exposure.
语种	英语
出版者	INT J MOL SCI
内容类型	期刊论文
源URL	[http://dspace.xmu.edu.cn/handle/2288/93248]
专题	医学院－已发表论文
推荐引用方式 GB/T 7714	Xiong, Xiang-Hua,Zhao, Yan,Ge, Xin,et al. Production and Radioprotective Effects of Pyrroloquinoline Quinone[J]. http://dx.doi.org/10.3390/ijms12128913,2011.
APA	Xiong, Xiang-Hua.,Zhao, Yan.,Ge, Xin.,Yuan, Shou-Jun.,Wang, Jian-Hua.,...&赵岩.(2011).Production and Radioprotective Effects of Pyrroloquinoline Quinone.http://dx.doi.org/10.3390/ijms12128913.
MLA	Xiong, Xiang-Hua,et al."Production and Radioprotective Effects of Pyrroloquinoline Quinone".http://dx.doi.org/10.3390/ijms12128913 (2011).