Activated hepatic stellate cells promote hepatocellular carcinoma development in immunocompetent mice

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	Activated hepatic stellate cells promote hepatocellular carcinoma development in immunocompetent mice
	Zhao, Wenxiu ; Zhang, Lei ; Yin, Zhenyu ; Su, Weixue ; Ren, Guangli ; Zhou, Changsheng ; You, Junyong ; Fan, Jia ; Wang, Xiaomin ; Yin ZY(尹震宇) ; Wang XM(王效民)
刊名	http://dx.doi.org/10.1002/ijc.25920
	2011-12-01
关键词	REGULATORY T-CELLS TUMOR-IMMUNITY STROMAL CELLS CANCER MECHANISM APOPTOSIS B7-H1 HEPATOCARCINOMA FIBROBLASTS EXPRESSION
英文摘要	National Key Sci-Tech Special Project of China [2008ZX10002-019]; National Natural Science Foundation of China [30872484]; Activated hepatic stellate cells (HSCs) play a central role in the hepatic fibrosis and cirrhosis. Recently, HSCs were reported to have strong immune modulatory activities. However, the role of HSCs in hepatocellular carcinoma (HCC) remains unclear. In this study, we showed that HSCs could promote HCC growth both in vitro and in vivo. We examined the HSC-mediated inhibition of T-cell proliferation and the ability of conditioned medium from activated HSCs to promote the growth of murine HCC cell lines in vitro. We also assessed the immune suppression by HSCs during the development of HCC in immunocompetent mice. Cotransplantation of HSCs promoted HCC growth and progression by enhancing tumor angiogenesis and tumor cell proliferation and by creating an immunosuppressed microenvironment. Cotransplanted HSCs inhibited the lymphocyte infiltration in tumors and the spleens of mice bearing tumors, induced apoptosis of infiltrating mononuclear cells, and enhanced the expression of B7H1 and CD4(+)CD25(+) Treg cells. The immune modulation by HSCs seemed to be systemic. In conclusion, our data provide new information to support an integral role for HSCs in promoting HCC progression in part via their immune regulatory activities, and suggest that HSCs may serve as a therapeutic target in HCC.
语种	英语
出版者	INT J CANCER
内容类型	期刊论文
源URL	[http://dspace.xmu.edu.cn/handle/2288/93240]
专题	医学院－已发表论文
推荐引用方式 GB/T 7714	Zhao, Wenxiu,Zhang, Lei,Yin, Zhenyu,et al. Activated hepatic stellate cells promote hepatocellular carcinoma development in immunocompetent mice[J]. http://dx.doi.org/10.1002/ijc.25920,2011.
APA	Zhao, Wenxiu.,Zhang, Lei.,Yin, Zhenyu.,Su, Weixue.,Ren, Guangli.,...&王效民.(2011).Activated hepatic stellate cells promote hepatocellular carcinoma development in immunocompetent mice.http://dx.doi.org/10.1002/ijc.25920.
MLA	Zhao, Wenxiu,et al."Activated hepatic stellate cells promote hepatocellular carcinoma development in immunocompetent mice".http://dx.doi.org/10.1002/ijc.25920 (2011).