Structural Modifications of the Brain in Acclimatization to High-Altitude

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	Structural Modifications of the Brain in Acclimatization to High-Altitude
	Zhang, Jiaxing ; Yan, Xiaodan ; Shi, Jinfu ; Gong, Qiyong ; Weng, Xuchu ; Liu, Yijun ; Zhang JX(张家兴)
刊名	http://dx.doi.org/10.1371/journal.pone.0011449
	2010-07-06
关键词	OBSTRUCTIVE SLEEP-APNEA VOXEL-BASED MORPHOMETRY HYPOXIC VENTILATORY RESPONSIVENESS MILD COGNITIVE IMPAIRMENT ANTERIOR CINGULATE CORTEX CHRONIC MOUNTAIN-SICKNESS SUBJECT DIFFUSION DATA FRACTIONAL ANISOTROPY SPATIAL STATISTICS PREFRONTAL CORTEX
英文摘要	National Science Foundation of China [30425008, 60628101]; Ministry of Science and Technology [2007CB512300]; China Postdoctoral Science Foundation [20060390129]; Adaptive changes in respiratory and cardiovascular responses at high altitude (HA) have been well clarified. However, the central mechanisms underlying HA acclimatization remain unclear. Using voxel-based morphometry (VBM) and diffusion tensor imaging (DTI) with fractional anisotropy (FA) calculation, we investigated 28 Han immigrant residents (17-22 yr) born and raised at HA of 2616-4200 m in Qinghai-Tibetan Plateau for at least 17 years and who currently attended college at sea-level (SL). Their family migrated from SL to HA 2-3 generations ago and has resided at HA ever since. Control subjects were matched SL residents. HA residents (vs. SL) showed decreased grey matter volume in the bilateral anterior insula, right anterior cingulate cortex, bilateral prefrontal cortex, left precentral cortex, and right lingual cortex. HA residents (vs. SL) had significantly higher FA mainly in the bilateral anterior limb of internal capsule, bilateral superior and inferior longitudinal fasciculus, corpus callosum, bilateral superior corona radiata, bilateral anterior external capsule, right posterior cingulum, and right corticospinal tract. Higher FA values in those regions were associated with decreased or unchanged radial diffusivity coinciding with no change of longitudinal diffusivity in HA vs. SL group. Conversely, HA residents had lower FA in the left optic radiation and left superior longitudinal fasciculus. Our data demonstrates that HA acclimatization is associated with brain structural modifications, including the loss of regional cortical grey matter accompanied by changes in the white matter, which may underlie the physiological adaptation of residents at HA.
语种	英语
出版者	PLOS ONE
内容类型	期刊论文
源URL	[http://dspace.xmu.edu.cn/handle/2288/93211]
专题	医学院－已发表论文
推荐引用方式 GB/T 7714	Zhang, Jiaxing,Yan, Xiaodan,Shi, Jinfu,et al. Structural Modifications of the Brain in Acclimatization to High-Altitude[J]. http://dx.doi.org/10.1371/journal.pone.0011449,2010.
APA	Zhang, Jiaxing.,Yan, Xiaodan.,Shi, Jinfu.,Gong, Qiyong.,Weng, Xuchu.,...&张家兴.(2010).Structural Modifications of the Brain in Acclimatization to High-Altitude.http://dx.doi.org/10.1371/journal.pone.0011449.
MLA	Zhang, Jiaxing,et al."Structural Modifications of the Brain in Acclimatization to High-Altitude".http://dx.doi.org/10.1371/journal.pone.0011449 (2010).