Efficacy of Mesenchymal Stem Cells Derived from Human Adipose Tissue in Inhibition of Hepatocellular Carcinoma Cells In Vitro

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	Efficacy of Mesenchymal Stem Cells Derived from Human Adipose Tissue in Inhibition of Hepatocellular Carcinoma Cells In Vitro
	Zhao, Wenxiu ; Ren, Guangli ; Zhang, Lei ; Zhang, Zhengqi ; Liu, Jianming ; Kuang, Penghao ; Yin, Zhenyu ; Wang, Xiaomin ; Yin ZY(尹震宇) ; Wang XM(王效民)
刊名	http://dx.doi.org/10.1089/cbr.2011.1150
	2012-11
关键词	STROMAL CELLS PROSTATE TUMOR CANCER-CELLS BONE-MARROW GROWTH DIFFERENTIATION EXPRESSION THERAPIES APOPTOSIS DEATH
英文摘要	National Natural Science Foundation of China [81171967]; National Key Sci-Tech Special Project of China [2012ZX10002011-005]; Projects of Xiamen Science and Technology Program [3502Z20114010]; Public Health Department of Fujian Foundation for Young Scientists [2009-2-65]; Hepatocellular carcinoma (HCC) is often diagnosed at an advanced stage, and over the past several decades, many researchers have worked to develop novel effective therapies for HCC patients. The functional contributions of mesenchymal stem cells to human malignancies, including HCC growth and progression, are controversial, and the potential mechanisms underlying these effects are not clear. The aim of this study was to investigate the effect of adipose-derived mesenchymal stem cells (ADSCs) on the growth of HCC cells. In this study, a conditioned medium from ADSCs (ADSC-CM) efficiently inhibited HCC cell proliferation and division, and induced HCC cell death through the downregulation of Akt signaling. These findings indicated that the ADSC-CM could inhibit HCC growth. Thus, the ADSC-CM is a good candidate for the treatment of HCC patients for whom no effective therapy is available.
语种	英语
出版者	CANCER BIOTHER RADIO
内容类型	期刊论文
源URL	[http://dspace.xmu.edu.cn/handle/2288/93101]
专题	医学院－已发表论文
推荐引用方式 GB/T 7714	Zhao, Wenxiu,Ren, Guangli,Zhang, Lei,et al. Efficacy of Mesenchymal Stem Cells Derived from Human Adipose Tissue in Inhibition of Hepatocellular Carcinoma Cells In Vitro[J]. http://dx.doi.org/10.1089/cbr.2011.1150,2012.
APA	Zhao, Wenxiu.,Ren, Guangli.,Zhang, Lei.,Zhang, Zhengqi.,Liu, Jianming.,...&王效民.(2012).Efficacy of Mesenchymal Stem Cells Derived from Human Adipose Tissue in Inhibition of Hepatocellular Carcinoma Cells In Vitro.http://dx.doi.org/10.1089/cbr.2011.1150.
MLA	Zhao, Wenxiu,et al."Efficacy of Mesenchymal Stem Cells Derived from Human Adipose Tissue in Inhibition of Hepatocellular Carcinoma Cells In Vitro".http://dx.doi.org/10.1089/cbr.2011.1150 (2012).