Abdominal Hernia Repair With a Decellularized Dermal Scaffold Seeded With Autologous Bone Marrow-Derived Mesenchymal Stem Cells

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	Abdominal Hernia Repair With a Decellularized Dermal Scaffold Seeded With Autologous Bone Marrow-Derived Mesenchymal Stem Cells
	Zhao, Yilin ; Zhang, Zhigang ; Wang, Jinling ; Yin, Ping ; Zhou, Jianyin ; Zhen, Maochuan ; Cui, Wugeng ; Xu, Gang ; Yang, Donghai ; Liu, Zhongchen ; Liu ZC(刘忠臣) ; Zhao YL(赵一麟) ; Yin P(殷平)
刊名	http://dx.doi.org/10.1111/j.1525-1594.2011.01343.x
	2012-03
关键词	SMALL-INTESTINAL SUBMUCOSA WALL HERNIA MATRIX DIFFERENTIATION TISSUE MESH TRANSPLANTATION RECONSTRUCTION REGENERATION DELIVERY
英文摘要	Surgeons usually use synthetic polymer meshes for abdominal wall hernia repair. However, synthetic polymer meshes exhibit a lack of growth and related complications. In this study, we produced a tissue-engineered patch for abdominal hernia repair. Autologous bone-marrow-derived mesenchymal stem cells (BMSCs) were isolated and proliferated in vitro; decellularized dermal scaffolds (DSs) were prepared using enzymatic process; and then BMSCs were seeded onto the DSs for the construction of tissue-engineered patches. Under general anesthesia, rabbits underwent creation of abdominal wall defects and which were repaired with BMSC-seeded DSs, acellular DSs, and skin sutures only, respectively. Animals were sacrificed after 2 months for assessing the histological and gross examination. Abdominal hernias were absent in animals repaired with cell-seeded group, and abdominal hernias or bulges appeared in all animals repaired with acellular group. All the animals that were not repaired died within 10 days. The cell-seeded implants were thicker and indicated good angiogenesis compared with that of the acellular implants, both in histological and gross examination. The tissue-engineered patches prepared with BMSCs seeding on DSs can be used for abdominal wall hernia repair.
语种	英语
出版者	ARTIF ORGANS
内容类型	期刊论文
源URL	[http://dspace.xmu.edu.cn/handle/2288/93094]
专题	医学院－已发表论文
推荐引用方式 GB/T 7714	Zhao, Yilin,Zhang, Zhigang,Wang, Jinling,et al. Abdominal Hernia Repair With a Decellularized Dermal Scaffold Seeded With Autologous Bone Marrow-Derived Mesenchymal Stem Cells[J]. http://dx.doi.org/10.1111/j.1525-1594.2011.01343.x,2012.
APA	Zhao, Yilin.,Zhang, Zhigang.,Wang, Jinling.,Yin, Ping.,Zhou, Jianyin.,...&殷平.(2012).Abdominal Hernia Repair With a Decellularized Dermal Scaffold Seeded With Autologous Bone Marrow-Derived Mesenchymal Stem Cells.http://dx.doi.org/10.1111/j.1525-1594.2011.01343.x.
MLA	Zhao, Yilin,et al."Abdominal Hernia Repair With a Decellularized Dermal Scaffold Seeded With Autologous Bone Marrow-Derived Mesenchymal Stem Cells".http://dx.doi.org/10.1111/j.1525-1594.2011.01343.x (2012).