Peptide derived from Pvfp-1 as bioadhesive on bio-inert surface

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	Peptide derived from Pvfp-1 as bioadhesive on bio-inert surface
	Jiang, Zhen ; Yu, Yabiao ; Du, Lina ; Ding, Xiyu ; Xu, Hui ; Sun, Yanan ; Zhang, Qiqing ; Zhang QQ(张其清)
刊名	http://dx.doi.org/10.1016/j.colsurfb.2011.10.037
	2012-02-01
关键词	MUSSEL ADHESIVE PROTEIN CELL-ADHESION MARINE MUSSEL ESCHERICHIA-COLI PRECURSOR PROTEIN MYTILUS-EDULIS MODEL PEPTIDE EXPRESSION DOPA POLYTETRAFLUOROETHYLENE
英文摘要	National Natural Science Foundation of China [20725310, 90923042, 30900305]; Fundamental Research Funds for the Central Universities [2010121023]; key laboratory of Biomedical Material of Tianjin; Surface property is one important characteristic of materials, especially for ones that are bio-inert but designed for bin-medical application. In this study, we designed a series of peptides and compared their capacities as bioadhesive to improve the surface bioactivity of bio-inert material. The peptides were designed according to the sequence of Perna viridis foot protein 1 (Pvfp-1), one of the Mfp-1s (mussel foot protein 1) which play key roles in wet adhesion of mussel byssus. And the Teflon (PTFE) was chosen as a model of bio-inert material. With adsorption, adhesion and coating analysis, it was found that peptide C2 (M) (derived from the non-repeating region of Pvfp-1, contains modified DOPA) has superior coating and adhesion abilities especially on the bio-inert surface of PTFE. After coating with peptide C2 (M), the cell adhesion and spreading of osteoblast MC3T3-E1 cells on PTFE were significantly improved compared with those on non-coated surface, and the peptide-coating did not show any cell toxicity. Therefore. peptide C2 (M) is effective for improving the bioactivity of bio-inert PTFE, and could be potentially used as a bioadhesive on other bin-inert materials for biomedical application. Moreover, this study also provided new insights in designing other peptide-based bioadhesive materials. (C) 2011 Elsevier B.V. All rights reserved.
语种	英语
内容类型	期刊论文
源URL	[http://dspace.xmu.edu.cn/handle/2288/71448]
专题	医学院－已发表论文
推荐引用方式 GB/T 7714	Jiang, Zhen,Yu, Yabiao,Du, Lina,et al. Peptide derived from Pvfp-1 as bioadhesive on bio-inert surface[J]. http://dx.doi.org/10.1016/j.colsurfb.2011.10.037,2012.
APA	Jiang, Zhen.,Yu, Yabiao.,Du, Lina.,Ding, Xiyu.,Xu, Hui.,...&张其清.(2012).Peptide derived from Pvfp-1 as bioadhesive on bio-inert surface.http://dx.doi.org/10.1016/j.colsurfb.2011.10.037.
MLA	Jiang, Zhen,et al."Peptide derived from Pvfp-1 as bioadhesive on bio-inert surface".http://dx.doi.org/10.1016/j.colsurfb.2011.10.037 (2012).