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	MicroRNA-24 regulates cardiac fibrosis after myocardial infarction
	Wang, Jue ; Huang, Weicong ; Xu, Ruixia ; Nie, Yu ; Cao, Xiaoqing ; Meng, Jiang ; Xu, Xiuqin ; Xu XQ(徐秀琴) ; Hu, Shengshou ; Zheng, Zhe
	2012-09
关键词	myocardial infarction cardiac fibrosis microRNA-24 furin TGF-ss telocyte
英文摘要	Cardiac fibrosis after myocardial infarction (MI) has been identified as a key factor in the development of heart failure. Although dysregulation of microRNA (miRNA) is involved in various pathophysiological processes in the heart, the role of miRNA in fibrosis regulation after MI is not clear. Previously we observed the correlation between fibrosis and the miR-24 expression in hypertrophic hearts, herein we assessed how miR-24 regulates fibrosis after MI. Using qRT-PCR, we showed that miR-24 was down-regulated in the MI heart; the change in miR-24 expression was closely related to extracellular matrix (ECM) remodelling. In vivo, miR-24 could improve heart function and attenuate fibrosis in the infarct border zone of the heart two weeks after MI through intramyocardial injection of Lentiviruses. Moreover, in vitro experiments suggested that up-regulation of miR-24 by synthetic miR-24 precursors could reduce fibrosis and also decrease the differentiation and migration of cardiac fibroblasts (CFs). TGF-beta (a pathological mediator of fibrotic disease) increased miR-24 expression, overexpression of miR-24 reduced TGF-beta secretion and Smad2/3 phosphorylation in CFs. By performing microarray analyses and bioinformatics analyses, we found furin to be a potential target for miR-24 in fibrosis (furin is a protease which controls latent TGF-beta activation processing). Finally, we demonstrated that protein and mRNA levels of furin were regulated by miR-24 in CFs. These findings suggest that miR-24 has a critical role in CF function and cardiac fibrosis after MI through a furinTGF-beta pathway. Thus, miR-24 may be used as a target for treatment of MI and other fibrotic heart diseases.; Natural Science Foundation of China [30872538, 81170130]; Major State Basic Research Development Program of China (973 Program) [2010CB529500]
语种	英语
出版者	WILEY-BLACKWELL
内容类型	期刊论文
源URL	[http://dx.doi.org/10.1111/j.1582-4934.2012.01523.x]
专题	医学院－已发表论文
推荐引用方式 GB/T 7714	Wang, Jue,Huang, Weicong,Xu, Ruixia,et al. MicroRNA-24 regulates cardiac fibrosis after myocardial infarction[J],2012.
APA	Wang, Jue.,Huang, Weicong.,Xu, Ruixia.,Nie, Yu.,Cao, Xiaoqing.,...&Zheng, Zhe.(2012).MicroRNA-24 regulates cardiac fibrosis after myocardial infarction..
MLA	Wang, Jue,et al."MicroRNA-24 regulates cardiac fibrosis after myocardial infarction".(2012).

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