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	Exposure to organochlorine pesticides is an independent risk factor of hepatocellular carcinoma: A case-control study
	Zhao, Benhua ; Zhao BH(赵本华) ; Shen, Heqing ; Liu, Feng ; Liu, Sheng ; Niu, Jianjun ; Guo, Fei ; Sun, Xueli
	2012-11
关键词	case-control study human exposure organochlorine pesticides primary hepatocellular carcinoma risk factor interaction
英文摘要	Primary hepatocellular carcinoma (HCC) is highly prevalent in China. Although hepatitis B virus (HBV) and aflatoxin B1 (AFB1) are considered the major risk factors, among the high-risk cohorts only a small fraction develops liver cancer. Therefore, we investigated whether organochlorine pesticide exposure contributed to HCC risk in the Xiamen population. The questionnaire database was built from 346 HCC cases and 961 healthy controls during 2007-2009. The serum levels of alpha-, beta-, gamma-, delta-HCH, 1,1,1-trichloro-2,2-bis (p-chlorophenyl) ethane (p,p'-DDT), (1,1-dichloro-2,2-bis (p-chlorophenyl) ethylene (p,p'-DDE), 1,1,1-trichloro-2,2-bis (o-chlorophenyl) ethane and 1,1-dichloro-2,2-bis (p-chlorophenyl) ethane were measured by gas chromatography-tandem mass spectrometer, and statistical analysis was done using SPSS16. Significantly, we observed p,p'-DDT and p,p'-DDE, and at the first time beta-HCH displayed quartile dose-dependent HCC risk trends; p,p'-DDT showed positive (i.e., synergistic) interactions with HBV, diabetes mellitus. AFB1 and polyaromatic hydrocarbon (PAH) exposure, but negative (i.e., antagonistic) interaction with heavy drinking; p,p'-DDE had positive interaction with PAH but negative interaction with HBV and p.p'-DDT; and beta-HCH positively interacted with p,p'-DDT but negatively interacted with heavy drinking and diabetes. p,p'-DDT, p,p'-DDE and beta-HCH were independent HCC risk factors. Because of their synergistic interactions with other factors, the high-level exposure combined with common AFB1 and HBV exposure in the investigated area may greatly enhance the risk of HCC. Journal of Exposure Science and Environmental Epidemiology (2012) 22, 541-548; doi:10.1038/jes.2011.29; published online 14 September 2011; Chinese Academy of Sciences (CAS) 100 Talents Program for Human Exposure; Xiamen Municipal Science and Technology Program [3502Z20073015]; CAS/SAFEA International Partnership Program for Creative Research Teams [KZCX2-YW-T08]; Ministry of Science and Technology of the People's Republic of China for Combined Pollution and Ecosystem Health in Urban Agglomeration [2009DFB90120]
语种	英语
出版者	NATURE PUBLISHING GROUP
内容类型	期刊论文
源URL	[http://dx.doi.org/10.1038/jes.2011.29]
专题	医学院－已发表论文
推荐引用方式 GB/T 7714	Zhao, Benhua,Zhao BH,Shen, Heqing,et al. Exposure to organochlorine pesticides is an independent risk factor of hepatocellular carcinoma: A case-control study[J],2012.
APA	Zhao, Benhua.,赵本华.,Shen, Heqing.,Liu, Feng.,Liu, Sheng.,...&Sun, Xueli.(2012).Exposure to organochlorine pesticides is an independent risk factor of hepatocellular carcinoma: A case-control study..
MLA	Zhao, Benhua,et al."Exposure to organochlorine pesticides is an independent risk factor of hepatocellular carcinoma: A case-control study".(2012).

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