NMR-based metabonomic analysis of MnO-embedded iron oxide nanoparticles as potential dual-modal contrast agents

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	NMR-based metabonomic analysis of MnO-embedded iron oxide nanoparticles as potential dual-modal contrast agents
	Li, Jinquan ; Zhou, Zijian ; Feng, Jianghua ; Cai, Shuhui ; Gao, Jinhao ; Chen, Zhong ; Feng JH(冯江华) ; Cai SH(蔡淑惠) ; Gao JH(高锦豪) ; Chen Z(陈忠)
刊名	http://dx.doi.org/10.1007/s11051-014-2411-5
	2014
关键词	Amides Amino acids Body fluids Detoxification Manganese oxide Metabolism Metal nanoparticles Nuclear magnetic resonance Phospholipids Plants (botany) Rats
英文摘要	MnO-embedded iron oxide nanoparticles (MnIO-NPs) can be treated as potential dual-modal contrast agents. However, their overall bio-effects and potential toxicity remain unknown. In this study, the metabolic effects of MnIO-NPs (dosed at 1 and 5 mg Fe/kg) on Sprague-Dawley rats were investigated using metabonomic analysis, histopathological examination, and conventional biochemical analysis. The histological changes included a focal inflammation in the liver at high-dose and a slightly enlarged area of splenic white pulp after 48 h post-dose. Blood biochemical analysis showed that albumin, globulins, aspartate aminotransferase, lactate dehydrogenase, blood urea nitrogen, and glucose changed distinctly compared to the control. The metabonomic analysis of body fluids (serum and urine) and tissues (liver, kidney, and spleen) indicated that MnIO-NPs induced metabolic perturbation in rats including energy, nucleotides, amino acids and phospholipid metabolisms. Besides, the variations of supportive nutrients: valine, leucine, isoleucine, nicotinamide adenine dinucleotide (phosphate), and nicotinamide, and the conjugation substrates: glycine, taurine, glutamine, glutathione, and methyl donors (formate, sarcosine, dimethylglycine, choline, and betaine) were involved in detoxification reaction of MnIO-NPs. The obtained information would provide identifiable ground for the candidate selection and optimization. ? Springer Science+Business Media 2014.
语种	英语
出版者	SPRINGER
内容类型	期刊论文
源URL	[http://dspace.xmu.edu.cn/handle/2288/92184]
专题	物理技术－已发表论文
推荐引用方式 GB/T 7714	Li, Jinquan,Zhou, Zijian,Feng, Jianghua,et al. NMR-based metabonomic analysis of MnO-embedded iron oxide nanoparticles as potential dual-modal contrast agents[J]. http://dx.doi.org/10.1007/s11051-014-2411-5,2014.
APA	Li, Jinquan.,Zhou, Zijian.,Feng, Jianghua.,Cai, Shuhui.,Gao, Jinhao.,...&陈忠.(2014).NMR-based metabonomic analysis of MnO-embedded iron oxide nanoparticles as potential dual-modal contrast agents.http://dx.doi.org/10.1007/s11051-014-2411-5.
MLA	Li, Jinquan,et al."NMR-based metabonomic analysis of MnO-embedded iron oxide nanoparticles as potential dual-modal contrast agents".http://dx.doi.org/10.1007/s11051-014-2411-5 (2014).