Engineered iron-oxide-based nanoparticles as enhanced T 1 contrast agents for efficient tumor imaging

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	Engineered iron-oxide-based nanoparticles as enhanced T 1 contrast agents for efficient tumor imaging
	Zhou, Zijian ; Wang, Lirong ; Chi, Xiaoqin ; Bao, Jianfeng ; Yang, Lijiao ; Zhao, Wenxiu ; Chen, Zhong ; Wang, Xiaomin ; Chen, Xiaoyuan ; Gao, Jinha ; Chen Z(陈忠) ; Gao JH(高锦豪)
刊名	http://dx.doi.org/10.1021/nn305991e
	2013-04-23
关键词	Gadolinium Iron oxides Tumors
英文摘要	We report the design and synthesis of small-sized zwitterion-coated gadolinium-embedded iron oxide (GdIO) nanoparticles, which exhibit a strong T1 contrast effect for tumor imaging through enhanced permeation and retention effect and the ability to clear out of the body in living subjects. The combination of spin-canting effects and the collection of gadolinium species within small-sized GdIO nanoparticles led to a significantly enhanced T 1 contrast effect. For example, GdIO nanoparticles with a diameter of ～4.8 nm exhibited a high r1 relaxivity of 7.85 mM -1·S-1 and a low r2/r1 ratio of 5.24. After being coated with zwitterionic dopamine sulfonate molecules, the 4.8 nm GdIO nanoparticles showed a steady hydrodynamic diameter (～5.2 nm) in both PBS buffer and fetal bovine serum solution, indicating a low nonspecific protein absorption. This study provides a valuable strategy for the design of highly sensitive iron-oxide-based T1 contrast agents with relatively long circulation half-lives (～50 min), efficient tumor passive targeting (SKOV3, human ovarian cancer xenograft tumor as a model), and the possibility of rapid renal clearance after tumor imaging. ? 2013 American Chemical Society.
语种	英语
出版者	American Chemical Society
内容类型	期刊论文
源URL	[http://dspace.xmu.edu.cn/handle/2288/91950]
专题	物理技术－已发表论文
推荐引用方式 GB/T 7714	Zhou, Zijian,Wang, Lirong,Chi, Xiaoqin,et al. Engineered iron-oxide-based nanoparticles as enhanced T 1 contrast agents for efficient tumor imaging[J]. http://dx.doi.org/10.1021/nn305991e,2013.
APA	Zhou, Zijian.,Wang, Lirong.,Chi, Xiaoqin.,Bao, Jianfeng.,Yang, Lijiao.,...&高锦豪.(2013).Engineered iron-oxide-based nanoparticles as enhanced T 1 contrast agents for efficient tumor imaging.http://dx.doi.org/10.1021/nn305991e.
MLA	Zhou, Zijian,et al."Engineered iron-oxide-based nanoparticles as enhanced T 1 contrast agents for efficient tumor imaging".http://dx.doi.org/10.1021/nn305991e (2013).