Molecular Diagnosis and Targeted Therapy of a Pediatric Chronic Eosinophilic Leukemia Patient Carrying TPM3-PDGFRB Fusion

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	Molecular Diagnosis and Targeted Therapy of a Pediatric Chronic Eosinophilic Leukemia Patient Carrying TPM3-PDGFRB Fusion
	Li, Zhipeng ; Yang, Rong ; Zhao, Jiangning ; Yuan, Ruirong ; Lu, Quanyi ; Li, Qingge ; Tse, William ; Zhao JN(赵俊宁)
刊名	http://dx.doi.org/10.1002/pbc.22800
	2011-03
关键词	GROWTH-FACTOR RECEPTOR CHRONIC MYELOPROLIFERATIVE DISORDERS CLUSTER REGION GENE IMATINIB PDGFRB TRANSLOCATIONS
英文摘要	Medical College of Xiamen University; We report a rare pediatric chronic eosinophilic leukemia (CEL) case of an 8-year-old male whose leukemic cells carried t(1; 5)(q21; q33) chromosomal abnormality. Sequencing analysis confirmed a TPM3-PDGFRB fusion, and the breakpoint was the same as adult patient. Targeted therapy with imatinib induced a rapid hematologic response and reduction of TPM3-PDGFRB transcripts as monitored by reverse transcription real-time PCR (RT-qPCR). We then established an RT-qPCR assay applicable to detection of all possible PDGFRB fusions and also validated this assay in the patient. These data should provide a valuable reference for management of pediatric CEL. Pediatr Blood Cancer 2011;56:463-466. (C) 2010 Wiley-Liss, Inc.
语种	英语
内容类型	期刊论文
源URL	[http://dspace.xmu.edu.cn/handle/2288/66625]
专题	数学科学－已发表论文
推荐引用方式 GB/T 7714	Li, Zhipeng,Yang, Rong,Zhao, Jiangning,et al. Molecular Diagnosis and Targeted Therapy of a Pediatric Chronic Eosinophilic Leukemia Patient Carrying TPM3-PDGFRB Fusion[J]. http://dx.doi.org/10.1002/pbc.22800,2011.
APA	Li, Zhipeng.,Yang, Rong.,Zhao, Jiangning.,Yuan, Ruirong.,Lu, Quanyi.,...&赵俊宁.(2011).Molecular Diagnosis and Targeted Therapy of a Pediatric Chronic Eosinophilic Leukemia Patient Carrying TPM3-PDGFRB Fusion.http://dx.doi.org/10.1002/pbc.22800.
MLA	Li, Zhipeng,et al."Molecular Diagnosis and Targeted Therapy of a Pediatric Chronic Eosinophilic Leukemia Patient Carrying TPM3-PDGFRB Fusion".http://dx.doi.org/10.1002/pbc.22800 (2011).