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	去乙酰真菌环氧乙酯的质量标准和稳定性研究; Study on the Quality Standard and Stability for Deacetylmycoepoxydiene
	徐莹 ; 黄耀坚 ; 张连茹 ; 黄欢 ; 郑忠辉 ; 沈月毛
	2010
关键词	去乙酰真菌环氧乙酯 质量标准 稳定性 deacetylmycoepoxydiene quality standard stability
英文摘要	采用高效液相色谱、红外光谱和热失重等技术,结合影响因素实验、加速实验和长期实验等方法,对抗肿瘤候选药物——去乙酰真菌环氧乙酯(dAM)的性状、鉴别、含量测定以及对光、热等稳定性进行研究.建立了dAM的鉴别和含量测定方法等相应的质量标准;稳定性实验结果表明:dAM对光、热均具有较好的稳定性,提示其可以在密闭常温条件下贮存,为dAM的后续开发奠定了基础.; Deacetylmycoepoxydiene has been proved to be a new and promising anticancer drug by pharmacology and toxicology.By means of influential factor experiment,accelerating experiment and long-term experiment,using the techniques of HPLC,IR,UV and thermal gravitational analysis,the character,identification,purity investigation,content determination and the stability for light,heat of deacetylmycoepoxydiene was studied.And the standard for qualith of deacetylmycoepoxydiene was set up.The stability experiment showed that deacetylmycoepoxydiene has a good stability under the harsh condition of high temperature,high moisture and violet light.The results suggested that deacetylmycoepoxydiene can be stored at airtight and common temperature conditions.This study laid the foundation for open and development deacetylmycoepoxydiene in industrialization.; 国家863计划(2007AA091503);厦门市科技项目(3502Z20093014)
语种	zh_CN
内容类型	期刊论文
源URL	[http://dspace.xmu.edu.cn/handle/2288/119009]
专题	生命科学－已发表论文
推荐引用方式 GB/T 7714	徐莹,黄耀坚,张连茹,等. 去乙酰真菌环氧乙酯的质量标准和稳定性研究, Study on the Quality Standard and Stability for Deacetylmycoepoxydiene[J],2010.
APA	徐莹,黄耀坚,张连茹,黄欢,郑忠辉,&沈月毛.(2010).去乙酰真菌环氧乙酯的质量标准和稳定性研究..
MLA	徐莹,et al."去乙酰真菌环氧乙酯的质量标准和稳定性研究".(2010).

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