Biodegradable gold nanovesicles with an ultrastrong plasmonic coupling effect for photoacoustic imaging and photothermal therapy

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	Biodegradable gold nanovesicles with an ultrastrong plasmonic coupling effect for photoacoustic imaging and photothermal therapy
	Huang, Peng ; Lin, Jing ; Li, Wanwan ; Rong, Pengfei ; Wang, Z ; Wang, Shouju ; Wang, Xiaoping ; Sun, Xiaolian ; Aronova, Maria ; Niu, Gang ; Leapman, Richard D. ; Nie, Zhihong ; Chen, Xiaoyuan ; Wang Z(王哲) ; Wang XP(王小平) ; Chen XY(陈小元)
刊名	http://dx.doi.org/10.1002/anie.201308986
	2013-12-23
关键词	Block copolymers Conversion efficiency Covalent bonds Electronic properties Gold Grafting (chemical) Infrared devices Medical applications Medical imaging Metal nanoparticles Photoacoustic effect Polyethylene glycols Polyethylene o
英文摘要	The hierarchical assembly of gold nanoparticles (GNPs) allows the localized surface plasmon resonance peaks to be engineered to the near-infrared (NIR) region for enhanced photothermal therapy (PTT). Herein we report a novel theranostic platform based on biodegradable plasmonic gold nanovesicles for photoacoustic (PA) imaging and PTT. The disulfide bond at the terminus of a PEG-b-PCL block-copolymer graft enables dense packing of GNPs during the assembly process and induces ultrastrong plasmonic coupling between adjacent GNPs. The strong NIR absorption induced by plasmon coupling and very high photothermal conversion efficiency (η=37 %) enable simultaneous thermal/PA imaging and enhanced PTT efficacy with improved clearance of the dissociated particles after the completion of PTT. The assembly of various nanocrystals with tailored optical, magnetic, and electronic properties into vesicle architectures opens new possibilities for the construction of multifunctional biodegradable platforms for biomedical applications. They do their job and clear out: A disulfide-terminated copolymer graft enabled the dense packing of gold nanoparticles (GNPs) into biodegradable plasmonic gold vesicles for simultaneous thermal/photoacoustic cancer imaging and photothermal therapy (PTT; see picture). The ultrastrong plasmonic coupling effect between adjacent GNPs led to a strong near-infrared (NIR) absorption and very high photothermal conversion efficiency (η=37 %). Copyright ? 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
语种	英语
出版者	Wiley-VCH Verlag
内容类型	期刊论文
源URL	[http://dspace.xmu.edu.cn/handle/2288/90748]
专题	生命科学－已发表论文
推荐引用方式 GB/T 7714	Huang, Peng,Lin, Jing,Li, Wanwan,et al. Biodegradable gold nanovesicles with an ultrastrong plasmonic coupling effect for photoacoustic imaging and photothermal therapy[J]. http://dx.doi.org/10.1002/anie.201308986,2013.
APA	Huang, Peng.,Lin, Jing.,Li, Wanwan.,Rong, Pengfei.,Wang, Z.,...&陈小元.(2013).Biodegradable gold nanovesicles with an ultrastrong plasmonic coupling effect for photoacoustic imaging and photothermal therapy.http://dx.doi.org/10.1002/anie.201308986.
MLA	Huang, Peng,et al."Biodegradable gold nanovesicles with an ultrastrong plasmonic coupling effect for photoacoustic imaging and photothermal therapy".http://dx.doi.org/10.1002/anie.201308986 (2013).