BASIC AND TRANSLATIONAL-PANCREAS

CORC > 厦门大学 > 生命科学－已发表论文

	BASIC AND TRANSLATIONAL-PANCREAS
	Gao, Tao ; Zhou, Dawang ; Yang, Chenghua ; Singh, Tarjinder ; Penzo-Mendez, Alfredo ; Maddipati, Ravikanth ; Tzatsos, Alexandros ; Bardeesy, Nabeel ; Avruch, Joseph ; Stanger, Ben Z. ; Zhou DW(周大旺)
刊名	http://dx.doi.org/10.1053/j.gastro.2013.02.037
	2013
关键词	HIPPO SIGNALING PATHWAY ORGAN SIZE CONTROL YAP KINASES LIVER MST1 PROLIFERATION INACTIVATION REGENERATION MAMMALS
英文摘要	BACKGROUND & AIMS: The Hippo signaling pathway is a context-dependent regulator of cell proliferation, differentiation, and apoptosis in species ranging from Drosophila to humans. In this study, we investigated the role of the core Hippo kinases-Mst1 and Mst2-in pancreatic development and homeostasis. METHODS: We used a Cre/LoxP system to create mice with pancreas-specific disruptions in Mst1 and Mst2 (Pdx1-Cre; Mst1(-/-); Mst2(fl/fl) mice), the mammalian orthologs of Drosophila Hippo. We used a transgenic approach to overexpress Yap, the downstream mediator of Hippo signaling, in the developing pancreas of mice. RESULTS: Contrary to expectations, the pancreatic mass of Pdx1-Cre; Mst1(-/-); Mst2(fl/fl) mice was reduced compared with wild-type mice, largely because of postnatal de-differentiation of acinar cells into duct-like cells. Development of this phenotype coincided with postnatal reactivation of YAP expression. Ectopic expression of YAP during the secondary transition (a stage at which YAP is normally absent) blocked differentiation of the endocrine and exocrine compartments, whereas loss of a single Yap allele reduced acinar de-differentiation. The phenotype of Pdx1-Cre; Mst1(-/-); Mst2(fl/fl) mice recapitulated cellular and molecular changes observed during chemicalinduced pancreatitis in mice. CONCLUSIONS: The mammalian Hippo kinases, and YAP, maintain postnatal pancreatic acinar differentiation in mice.
语种	英语
出版者	W B SAUNDERS CO-ELSEVIER INC
内容类型	期刊论文
源URL	[http://dspace.xmu.edu.cn/handle/2288/90718]
专题	生命科学－已发表论文
推荐引用方式 GB/T 7714	Gao, Tao,Zhou, Dawang,Yang, Chenghua,et al. BASIC AND TRANSLATIONAL-PANCREAS[J]. http://dx.doi.org/10.1053/j.gastro.2013.02.037,2013.
APA	Gao, Tao.,Zhou, Dawang.,Yang, Chenghua.,Singh, Tarjinder.,Penzo-Mendez, Alfredo.,...&周大旺.(2013).BASIC AND TRANSLATIONAL-PANCREAS.http://dx.doi.org/10.1053/j.gastro.2013.02.037.
MLA	Gao, Tao,et al."BASIC AND TRANSLATIONAL-PANCREAS".http://dx.doi.org/10.1053/j.gastro.2013.02.037 (2013).