Mst1 and Mst2 kinases: regulations and diseases

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	Mst1 and Mst2 kinases: regulations and diseases
	Qin, Funiu ; Tian, Jing ; Zhou, Dawang ; Chen, Lanfen ; Zhou DW(周大旺) ; Chen LF(陈兰芬)
刊名	http://dx.doi.org/10.1186/2045-3701-3-31
	2013
关键词	RHO FAMILY GTPASES ORGAN SIZE CONTROL CELL-CYCLE EXIT TUMOR-SUPPRESSOR HIPPO PATHWAY OXIDATIVE-STRESS PROMOTES APOPTOSIS PROTEIN-KINASE CARDIOMYOCYTE PROLIFERATION TRANSCRIPTION FACTOR
英文摘要	China's 1000 Young Talents Program; 111 Project of the Ministration of Education of China [B06016]; Fundamental Research Funds for the Central Universities of China [2010111079]; National Natural Science Foundation of China [81101503/H1602, 31270918/C080101, 81222030/H1602]; Natural Science Foundation of Fujian [2011J05096]; Program of Introducing Talents of Discipline to Universities [B12001]; The Hippo signaling pathway has emerged as a critical regulator for organ size control. The serine/threonine protein kinases Mst1 and Mst2, mammalian homologs of the Hippo kinase from Drosophila, play the central roles in the Hippo pathway controlling the cell proliferation, differentiation, and apoptosis during development. Mst1/2 can be activated by cellular stressors and the activation of Mst1/2 might enforce a feedback stimulation system to regulate oxidant levels through several mechanisms, in which regulation of cellular redox state might represent a tumor suppressor function of Mst1/2. As in Drosophila, murine Mst1/Mst2, in a redundant manner, negatively regulate the Yorkie ortholog YAP in multiple organs, although considerable diversification in the pathway composition and regulation is observed in some of them. Generally, loss of both Mst1 and Mst2 results in hyperproliferation and tumorigenesis that can be largely negated by the reduction or elimination of YAP. The Hippo pathway integrates with other signaling pathways e. g. Wnt and Notch pathways and coordinates with them to impact on the tumor pathogenesis and development. Furthermore, Mst1/2 kinases also act as an important regulator in immune cell activation, adhesion, migration, growth, and apoptosis. This review will focus on the recent updates on those aspects for the roles of Mst1/2 kinases.
语种	英语
出版者	BIOMED CENTRAL LTD
内容类型	期刊论文
源URL	[http://dspace.xmu.edu.cn/handle/2288/90699]
专题	生命科学－已发表论文
推荐引用方式 GB/T 7714	Qin, Funiu,Tian, Jing,Zhou, Dawang,et al. Mst1 and Mst2 kinases: regulations and diseases[J]. http://dx.doi.org/10.1186/2045-3701-3-31,2013.
APA	Qin, Funiu,Tian, Jing,Zhou, Dawang,Chen, Lanfen,周大旺,&陈兰芬.(2013).Mst1 and Mst2 kinases: regulations and diseases.http://dx.doi.org/10.1186/2045-3701-3-31.
MLA	Qin, Funiu,et al."Mst1 and Mst2 kinases: regulations and diseases".http://dx.doi.org/10.1186/2045-3701-3-31 (2013).