Development of a hepatitis delta virus antibody assay for study of the prevalence of HDV among individuals infected with hepatitis B virus in China

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	Development of a hepatitis delta virus antibody assay for study of the prevalence of HDV among individuals infected with hepatitis B virus in China
	Shen, Liping ; Gu, Ying ; Sun, Le ; Yang, Yingchao ; Wang, Feng ; Li, Yimin ; Bi, Shengli ; Gu Y(顾颖)
刊名	http://dx.doi.org/10.1002/jmv.23212
	2012-03
关键词	EPIDEMIOLOGY ANTIGEN
英文摘要	Co-infection with hepatitis delta virus (HDV) and hepatitis B virus (HBV) has been shown to be associated with a more severe form of acute and chronic hepatitis. Cloning and expression of recombinant HDV antigen (rHDAg) in Escherichiacoli are described. Using purified rHDAg, a cost-effective indirect anti-HDV enzyme-linked immunosorbent assay (ELISA) kit was developed. Direct comparison of 15 known HDV-positive sera and 15 HDV-negative sera showed concordance agreement between the new assay kit and the Abbott Murex Anti-Delta (total) kit. In addition, 1,486 hepatitis B surface antigen (HBsAg) positive blood samples collected from various areas of China were tested using this indirect anti-HDV ELISA. It was found that 1.2% (95% CI: 0.71.9%) of the samples were anti-HDAg positive. It is suggested that the prevalence of HDV and HBV co-infection in China is relatively low. J. Med. Virol. 84:445449, 2012. (C) 2011 Wiley Periodicals, Inc.
语种	英语
内容类型	期刊论文
源URL	[http://dspace.xmu.edu.cn/handle/2288/65905]
专题	生命科学－已发表论文
推荐引用方式 GB/T 7714	Shen, Liping,Gu, Ying,Sun, Le,et al. Development of a hepatitis delta virus antibody assay for study of the prevalence of HDV among individuals infected with hepatitis B virus in China[J]. http://dx.doi.org/10.1002/jmv.23212,2012.
APA	Shen, Liping.,Gu, Ying.,Sun, Le.,Yang, Yingchao.,Wang, Feng.,...&顾颖.(2012).Development of a hepatitis delta virus antibody assay for study of the prevalence of HDV among individuals infected with hepatitis B virus in China.http://dx.doi.org/10.1002/jmv.23212.
MLA	Shen, Liping,et al."Development of a hepatitis delta virus antibody assay for study of the prevalence of HDV among individuals infected with hepatitis B virus in China".http://dx.doi.org/10.1002/jmv.23212 (2012).