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	Stimulation of glucose transport by AMP-activated protein kinase via activation of p38 mitogen-activated protein kinase
	Xi, X. ; Han, J. H. ; Zhang, J. Z. ; Han JH(韩家淮)
	2001
关键词	MAP KINASE 3T3-L1 ADIPOCYTES SKELETAL-MUSCLE OXIDATIVE-PHOSPHORYLATION 5-AMINOIMIDAZOLE-4-CARBOXAMIDE RIBONUCLEOSIDE SELECTIVE ACTIVATION GLUT4 TRANSLOCATION SIGNAL-TRANSDUCTION CLONE-9 CELLS INSULIN
英文摘要	Activation of AMP-activated protein kinase (AMPK) has been recently demonstrated to be associated with 5-aminoimidazole-4-carboxa;de ribonucleoside (AICAR)stimulated glucose transport mediated by both GLUT1 and GLUT4 transporters. However, signaling events upstream and downstream of AMPK are unknown. Here we report that 1) p38 mitogen-activated protein kinase (MAPK) and mitogen-activated protein kinase kinase 3 (MKK3) were activated by AICAR in Clone 9 cells, which express only the GLUT1 transporters, and 2) activation of p38 was required for AICAR-stimulated glucose transport since treatment of the cells with p38 inhibitor SB203580 or overexpression of dominant negative p38 mutant inhibited glucose transport. Moreover, we found that overexpression of the constitutively active form of AMPK mutant also resulted in a significant activation of p38, and inhibition of p38 activity by SB203580 did not affect AICAR-stimulated activation of AMPK. These findings demonstrate that AICAR-stimulated activation of p38 is indeed mediated by AMPK, and the p38 MAPK cascade is downstream of AMPK in the signaling pathway of AICAR-stimulated glucose transport in Clone 9 cells.
语种	英语
内容类型	期刊论文
源URL	[http://dspace.xmu.edu.cn/handle/2288/65845]
专题	生命科学－已发表论文
推荐引用方式 GB/T 7714	Xi, X.,Han, J. H.,Zhang, J. Z.,et al. Stimulation of glucose transport by AMP-activated protein kinase via activation of p38 mitogen-activated protein kinase[J],2001.
APA	Xi, X.,Han, J. H.,Zhang, J. Z.,&韩家淮.(2001).Stimulation of glucose transport by AMP-activated protein kinase via activation of p38 mitogen-activated protein kinase..
MLA	Xi, X.,et al."Stimulation of glucose transport by AMP-activated protein kinase via activation of p38 mitogen-activated protein kinase".(2001).

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