MLK4 has negative effect on TLR4 signaling

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	MLK4 has negative effect on TLR4 signaling
	Seit-Nebi, Alim ; Cheng, Wei ; Xu, Hong ; Han, Jiahuai ; Han JH(韩家淮)
刊名	http://dx.doi.org/10.1038/cmi.2011.15
	2012-01
关键词	TERMINAL KINASE ACTIVATION MIXED-LINEAGE KINASES NEURONAL APOPTOSIS BINDING MOTIF IN-VIVO PATHWAY P38 JNK PHOSPHORYLATION PROTEINS
英文摘要	NSF China [30830092, 30921005, 91029304, 81061160512]; 973 Program [2009CB522200]; National Institutes of Health [AI41637, AI68896]; The stimulation of Toll-like receptors (TLRs) on macrophages triggers production of proinflammatory cytokines such as tumor-necrosis factor-alpha (TNF-alpha). The TNF production is mediated by a series of signaling events and subsequent transcriptional and post-transcriptional activation of the TNF gene. Termination of TLR-mediated cellular signaling is also important for a proper immunoresponse, since sustained cytokine expression can result in immune disorders. Here we identified that mixed-lineage kinase (MLK) 4 is a TLR4-interacting protein. Unlike previously characterized MLK group members, MLK4 cannot act as a mitogen-activated protein kinase kinase kinase (MAP3K) to mediate c-Jun N-terminal kinase (JNK), p38 or extracellular signal-regulated kinase (ERK) activation. Rather, MLK4 appears to be able to inhibit lipopolysaccharide (LPS)-induced activation of the JNK or ERK pathways, but does not have effect on LPS-induced p38 or NF-kappa B activation. The LPS-induced TNF production in MLK4 knockdown and overexpression cells were also increased and reduced, respectively. These data demonstrate that MLK4 is a negative regulator of TLR4 signaling. Cellular & Molecular Immunology (2012) 9, 27-33; doi:10.1038/cmi.2011.15; published online 23 May 2011
语种	英语
内容类型	期刊论文
源URL	[http://dspace.xmu.edu.cn/handle/2288/65746]
专题	生命科学－已发表论文
推荐引用方式 GB/T 7714	Seit-Nebi, Alim,Cheng, Wei,Xu, Hong,et al. MLK4 has negative effect on TLR4 signaling[J]. http://dx.doi.org/10.1038/cmi.2011.15,2012.
APA	Seit-Nebi, Alim,Cheng, Wei,Xu, Hong,Han, Jiahuai,&韩家淮.(2012).MLK4 has negative effect on TLR4 signaling.http://dx.doi.org/10.1038/cmi.2011.15.
MLA	Seit-Nebi, Alim,et al."MLK4 has negative effect on TLR4 signaling".http://dx.doi.org/10.1038/cmi.2011.15 (2012).