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	CIDE-A, a novel link between brown adipose tissue and obesity
	Lin, S. C. ; Li, P. ; Lin SC(林圣彩)
	2004
关键词	MITOCHONDRIAL UNCOUPLING PROTEIN DNA-FRAGMENTATION-FACTOR BETA-CELL DYSFUNCTION DIET-INDUCED OBESITY HIGH-FAT DIET ENERGY-BALANCE ADAPTIVE THERMOGENESIS MICE LACKING PPAR-GAMMA TARGETED DISRUPTION
英文摘要	Brown adipose tissue (BAT) is the major site of adaptive thermogenesis in rodents. The thermogenic activity of BAT is mediated by uncoupling proteins (Ucp1). Impaired BAT activity is believed to have an important role in the development of obesity. However, direct evidence linking BAT to obesity is scarce. Cidea, which was initially identified as a result of its sequence similarity to the apoptotic DNA fragmentation factor, is highly expressed in BAT. Mice that are deficient for Cidea showed an increase in energy expenditure and are resistant to high-fat diet-induced obesity and diabetes. Although the precise mechanism by which Cidea regulates energy homeostasis is not yet clear, Cidea appears to interact with Ucp1 in mammalian cells and inhibits its uncoupling activity when co-expressed in yeast. Therefore, Cidea offers a new option to explore the linkage between BAT and obesity.
语种	英语
内容类型	期刊论文
源URL	[http://dspace.xmu.edu.cn/handle/2288/65320]
专题	生命科学－已发表论文
推荐引用方式 GB/T 7714	Lin, S. C.,Li, P.,Lin SC. CIDE-A, a novel link between brown adipose tissue and obesity[J],2004.
APA	Lin, S. C.,Li, P.,&林圣彩.(2004).CIDE-A, a novel link between brown adipose tissue and obesity..
MLA	Lin, S. C.,et al."CIDE-A, a novel link between brown adipose tissue and obesity".(2004).

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