Steroid Receptor Coactivator 3 Is Required for Clearing Bacteria and Repressing Inflammatory Response in Escherichia coli-Induced Septic Peritonitis

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	Steroid Receptor Coactivator 3 Is Required for Clearing Bacteria and Repressing Inflammatory Response in Escherichia coli-Induced Septic Peritonitis
	Chen, Q. A. ; Chen, T. H. ; Xu, Y. X. ; Zhu, J. W. ; Jiang, Y. A. ; Zhao, Y. ; Xu, J. M. ; Yu, C. D. ; Yu CD(俞春东)
刊名	http://dx.doi.org/10.4049/jimmunol.0903802
	2010-11-01
关键词	INNATE IMMUNE-RESPONSE OXYGEN SPECIES ROS GENE-EXPRESSION INDUCED APOPTOSIS SEPSIS INFECTION PHAGOCYTOSIS ACTIVATION CANCER SRC-3
英文摘要	National Natural Science Foundation of China [30600566, 30770455]; National Basic Research Program of China (973 Program) [2008CB517311, 2009CB522200]; Science Planning Program of Fujian Province [2009J1010]; National Institutes of Health [DK058242]; Steroid receptor coactivator 3 (SRC-3) is a multifunctional protein that plays an important role in regulation of bacterial LPS-induced inflammation. However, its involvement in host defense against bacterial infection remains unclear. In this study, we used SRC-3 knockout mice to assess the role of SRC-3 in antibacterial defense in Escherichia coli-induced septic peritonitis. After E. coli bacteria were injected i.p., SRC-3-deficient mice exhibited excessive local and systemic inflammatory responses and more severe bacterial burdens, leading to a significantly higher mortality compared with wild-type mice. Peritoneal macrophages of SRC-3-deficient mice showed a decrease in bacterial phagocytosis in culture and an increase in apoptosis, which was consistent with the defective bacterial clearance observed in SRC-3-deficient mice. Accordingly, SRC-3 null macrophages expressed much lower levels of scavenger receptor A, the antioxidant enzyme catalase, and antiapoptotic gene Bcl-2. Collectively, our data demonstrate that SRC-3 is important not only in modulating the local and systemic inflammation but also in intensifying bacterial clearance, which highlights a pivotal role of SRC-3 in the host defense system against bacterial infection. The Journal of Immunology, 2010, 185: 5444-5452.
语种	英语
内容类型	期刊论文
源URL	[http://dspace.xmu.edu.cn/handle/2288/64978]
专题	生命科学－已发表论文
推荐引用方式 GB/T 7714	Chen, Q. A.,Chen, T. H.,Xu, Y. X.,et al. Steroid Receptor Coactivator 3 Is Required for Clearing Bacteria and Repressing Inflammatory Response in Escherichia coli-Induced Septic Peritonitis[J]. http://dx.doi.org/10.4049/jimmunol.0903802,2010.
APA	Chen, Q. A..,Chen, T. H..,Xu, Y. X..,Zhu, J. W..,Jiang, Y. A..,...&俞春东.(2010).Steroid Receptor Coactivator 3 Is Required for Clearing Bacteria and Repressing Inflammatory Response in Escherichia coli-Induced Septic Peritonitis.http://dx.doi.org/10.4049/jimmunol.0903802.
MLA	Chen, Q. A.,et al."Steroid Receptor Coactivator 3 Is Required for Clearing Bacteria and Repressing Inflammatory Response in Escherichia coli-Induced Septic Peritonitis".http://dx.doi.org/10.4049/jimmunol.0903802 (2010).