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	Elevated cholesterol metabolism and bile acid synthesis in mice lacking membrane tyrosine kinase receptor FGFR4
	Yu, C. D. ; Wang, F. ; Kan, M. ; Jin, C. L. ; Jones, R. B. ; Weinstein, M. ; Deng, C. X. ; McKeehan, W. L. ; Yu CD(俞春东)
	2000
关键词	FIBROBLAST-GROWTH-FACTOR MESSENGER-RNA LEVELS HMG-COA REDUCTASE LIVER DEVELOPMENT NUCLEAR RECEPTOR OXYSTEROL 7-ALPHA-HYDROXYLASE COORDINATE REGULATION HEPARAN-SULFATE BINDING PROTEIN FACTOR FAMILY
英文摘要	Heparan sulfate-regulated transmembrane tyrosine kinase receptor FGFR4 is the major FGFR isotype in mature hepatocytes. Fibroblast growth factor has been implicated in the definition of liver from foregut endoderm where FGFR4 is expressed and stimulation of hepatocyte DNA synthesis in vitro, Here we show that livers of mice lacking FGFR4 exhibited normal morphology and regenerated normally in response to partial hepatectomy, However, the FGFR4 (-/-) mice exhibited depleted gallbladders, an elevated bile acid pool and elevated excretion of bile acids. Cholesterol- and bile acid-controlled liver cholesterol 7 alpha-hydroxylase, the limiting enzyme for bile acid synthesis, was elevated, unresponsive to dietary cholesterol, but repressed normally by dietary cholate, Expression pattern and cholate-dependent, cholesterol-induced hepatomegaly in the FGFR4 (-/-) mice suggested that activation of receptor interacting protein 140, a co-repressor of feed-forward activator liver X receptor alpha, may mediate the negative regulation of cholesterol- and bile acid-controlled liver cholesterol 7 alpha-hydroxylase transcription by FCFR4 and cholate, The results demonstrate that transmembrane sensors interface with metabolite-controlled transcription networks and suggest that pericellular matrix-controlled liver FGFR4 in particular may ensure adequate cholesterol for cell structures and signal transduction.
语种	英语
内容类型	期刊论文
源URL	[http://dspace.xmu.edu.cn/handle/2288/64977]
专题	生命科学－已发表论文
推荐引用方式 GB/T 7714	Yu, C. D.,Wang, F.,Kan, M.,et al. Elevated cholesterol metabolism and bile acid synthesis in mice lacking membrane tyrosine kinase receptor FGFR4[J],2000.
APA	Yu, C. D..,Wang, F..,Kan, M..,Jin, C. L..,Jones, R. B..,...&俞春东.(2000).Elevated cholesterol metabolism and bile acid synthesis in mice lacking membrane tyrosine kinase receptor FGFR4..
MLA	Yu, C. D.,et al."Elevated cholesterol metabolism and bile acid synthesis in mice lacking membrane tyrosine kinase receptor FGFR4".(2000).

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