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	Lysine methylation of FOXO3 regulates oxidative stress-induced neuronal cell death
	Xie, Qi ; Hao, Yumin ; Tao, Li ; Peng, Shengyi ; Rao, Chitong ; Chen, Hong ; You, Han ; You H(尤涵) ; Dong, Meng-qiu ; Yuan, Zengqiang
	2012-04
关键词	apoptosis FOXO3 methylation signal transduction
英文摘要	FOXO transcription factors have a critical role in oxidative stress-induced neuronal cell death. A variety of post-translational modifications of FOXO family proteins have been reported, including phosphorylation, acetylation, ubiqutination and recently arginine methylation. Here, we demonstrate that the methyltransferase Set9 methylates FOXO3 at lysine 270. Methylation of FOXO3 leads to the inhibition of its DNA-binding activity and transactivation. Accordingly, lysine methylation reduces oxidative stress-induced and FOXO3-mediated Bim expression and neuronal apoptosis in neurons. Collectively, these findings define a novel modification of FOXO3 and show that lysine methylation negatively regulates FOXO3-mediated transcription and neuronal apoptosis.; National Science Foundation of China [30870792, 81030025, 81125010]; Ministry of Science and Technology of China [973-2009CB918704, 2012CB910701]
语种	英语
出版者	NATURE PUBLISHING GROUP
内容类型	期刊论文
源URL	[http://dx.doi.org/10.1038/embor.2012.25]
专题	生命科学－已发表论文
推荐引用方式 GB/T 7714	Xie, Qi,Hao, Yumin,Tao, Li,et al. Lysine methylation of FOXO3 regulates oxidative stress-induced neuronal cell death[J],2012.
APA	Xie, Qi.,Hao, Yumin.,Tao, Li.,Peng, Shengyi.,Rao, Chitong.,...&Yuan, Zengqiang.(2012).Lysine methylation of FOXO3 regulates oxidative stress-induced neuronal cell death..
MLA	Xie, Qi,et al."Lysine methylation of FOXO3 regulates oxidative stress-induced neuronal cell death".(2012).

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