| Two New p-Terphenyl Derivatives from the Marine Fungal Strain Aspergillus sp AF119 | |
| Liu, Shao-Song ; Zhao, Bao-Bing ; Lu, Chun-Hua ; Huang, Jing-Jing ; Shen, Yue-Mao ; Shen YM(沈月毛) | |
| 2012-08 | |
| 关键词 | Aspergillus sp. Terphyl acid Terphyl diacid Cytotoxic activity ROS DNA double-strand break |
| 英文摘要 | Two new p-terphenyl derivatives (I, 2), together with six known ones (3 - 8), have been isolated from the marine fungal strain Aspergillus sp. AF119. The structures for terphyl acid (I) and terphyl diacid (2) were determined on the basis of HR Q-TOF-MS, and 1D- and 2D-NMR spectroscopic data. The in vitro cytotcxic activities of compounds I 8 were tested against human tumor cell lines HeLa, HepG-2 and MDA-MB-435; only compounds 5 8 exhibited inhibitory activity against the tested cell lines with IC50 values < 20 mu M. Moreover, compound 5 showed a mechanism of inducing cell cycle arrest and apoptosis mediated by the generation of ROS and subsequent DNA double-strand break.; NSFC [90913024, 31028019]; Chinese Ministry of Education [306010]; 973 program [2010CB833802] |
| 语种 | 英语 |
| 出版者 | NATURAL PRODUCTS INC |
| 内容类型 | 期刊论文 |
| 源URL | [http://www.ncbi.nlm.nih.gov/pubmed/22978228]  |
| 专题 | 生命科学－已发表论文 |
| 推荐引用方式 GB/T 7714 | Liu, Shao-Song,Zhao, Bao-Bing,Lu, Chun-Hua,et al. Two New p-Terphenyl Derivatives from the Marine Fungal Strain Aspergillus sp AF119[J],2012. |
| APA | Liu, Shao-Song,Zhao, Bao-Bing,Lu, Chun-Hua,Huang, Jing-Jing,Shen, Yue-Mao,&沈月毛.(2012).Two New p-Terphenyl Derivatives from the Marine Fungal Strain Aspergillus sp AF119.. |
| MLA | Liu, Shao-Song,et al."Two New p-Terphenyl Derivatives from the Marine Fungal Strain Aspergillus sp AF119".(2012). |
| 个性服务 |
| 查看访问统计 |
| 相关权益政策 |
| 暂无数据 |
| 收藏/分享 |
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。
修改评论