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	In vitro anti-inflammatory activity of 4-arylcoumarins from endophytic Streptomyces aureofaciens CMUAc130 in murine macrophage RAW 264.7 cells
	Taechowisan, Thongchai（Silpakorn Univ, Fac Sci, Dept Microbiol, Nakhon Pathom 73000, Thailand） ; Lu, Chunhua ; Lu CH(鲁春华) ; Shen, Yuemao ; Shen YM(沈月毛) ; Lumyong, Saisamorn（Chiang Mai Univ, Fac Sci, Dept Biol, Chiang Mai 50200, Thailand）
	2007
关键词	4-arylcoumarins anti-inflammatory activity endophytic streptomyces murine macrophage RAW 264.7 cells
英文摘要	This research was undertaken to find the in vitro inflammatory action of 5,7-dimethoxy4- p-methoxylphenylcoumarin and 5,7-dimethoxy-4-phenylcoumarin produced by Streptomyces aureofaciens CMUAc130. We investigated the effects of 5,7-dimethoxy-4-p-methoxylphenylcoumarin and 5,7-dimethoxy-4-phenylcoumarin not only on the formation of nitric oxide (NO), PGE(2), TNF-alpha, IL-6 and IL-1 beta, but also on inducible NO synthase and cyclooxygenase-2 (COX-2) in lipopolysaccharide (LPS)-induced murine macrophage RAW 264.7 cells. The data obtained were consistent with the modulation of iNOS enzyme expression. A similar fashion was also observed when LPS-induced PGE2 release and COX-2 expression were tested. The significant inhibitory effects were shown in concentration-dependent manners. In addition, 5,7-dimethoxy-4-p-methoxylphenylcoumarin and 5,7-dimethoxy-4-phenylcoumarin also mildly but significantly reduced the formation of TNF-alpha. These findings support the application of 5,7-dimethoxy-4-p-methoxylphenylcoumarin and 5,7-dimethoxy-4-phenylcoumarin as anti-inflammatory agents.
语种	英语
出版者	TAYLOR & FRANCIS LTD
内容类型	期刊论文
源URL	[http://dx.doi.org/doi:10.1080/14786410601129671]
专题	生命科学－已发表论文
推荐引用方式 GB/T 7714	Taechowisan, Thongchai,Lu, Chunhua,Lu CH,et al. In vitro anti-inflammatory activity of 4-arylcoumarins from endophytic Streptomyces aureofaciens CMUAc130 in murine macrophage RAW 264.7 cells[J],2007.
APA	Taechowisan, Thongchai,Lu, Chunhua,鲁春华,Shen, Yuemao,沈月毛,&Lumyong, Saisamorn.(2007).In vitro anti-inflammatory activity of 4-arylcoumarins from endophytic Streptomyces aureofaciens CMUAc130 in murine macrophage RAW 264.7 cells..
MLA	Taechowisan, Thongchai,et al."In vitro anti-inflammatory activity of 4-arylcoumarins from endophytic Streptomyces aureofaciens CMUAc130 in murine macrophage RAW 264.7 cells".(2007).

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