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	Localization of Nucleophosmin in Nuclear Matrix and Changes in Its Expression During the Differentiation of Human Neuroblastoma Induced by Retinoic Acid
	Shi, Song-Lin ; Shi SL(石松林) ; Liang, Ying ; Liang Y(梁盈) ; Li, Qi-Fu ; Li QF(李祺福) ; Jing, Guang-Jun ; Wang, San-Ying ; Zhang, Xiu-Yan ; Zhang XY(张秀艳) ; Wu, Fu-Yun
	2010-09-01
关键词	NUCLEOPHOSMIN NUCLEAR MATRIX HUMAN NEUROBLASTOMA CELL DIFFERENTIATION
英文摘要	In this study, female and male Thais clavigera whelks were exposed to aqueous and dietary (using oysteis as the prey) tributyltin gm for up to 45 days. followed by a 30-day depuration, in order to examine the gender differences in TBT accumulation and transformation The metabolites of TBT [dibutyltin (DBT) and monobutyltin (MBT)] were also measured in different tissues of the whelks (digestive, reproductive and remaining organs) during the exposure and depuration periods By the end of the exposure period. all of the female whelks developed imposex after TBT exposure, and both the relative penis size index and the vas deferens sequence index were positively correlated with the tissue burden of TBT However, biomagnification of TBT did not occur in the whelks. TBT was rapidly accumulated in their digestive and reproductive organs from both routes of exposure, and both elimination and biotransformation of TBT were also rapid The redistribution of TBT among tissues was obvious during the exposure period but negligible during depuration MBT was generally the major metabolite in each tissue, indicating a significant metabolism of TBT by the whelks Accumulation, transformation, as well as elimination, were more significant following dietary exposure than following aqueous exposure In particular, we observed gender-related differences in the biokinetics of TBT Rapid biotransformation and elimination of TBT were detected in the male whelks, while the female whelks had higher bioaccumulation but lower elimination of TBT in their reproductive organs Internal remobilization of TBT from digestive to reproductive organs was also more obvious in the females, indicating that the reproductive organs of females were the main targets of TBT accumulation (C) 2010 Elsevier B.V All rights reserved; National Natural Science Foundation of China [40476048]; 863 project [2007AA09Z126]; Marine Public Welfare Project of China [200805090]
语种	英语
出版者	WILEY-LISS
内容类型	期刊论文
源URL	[http://dx.doi.org/doi:10.1002/jcb.22663]
专题	生命科学－已发表论文
推荐引用方式 GB/T 7714	Shi, Song-Lin,Shi SL,Liang, Ying,et al. Localization of Nucleophosmin in Nuclear Matrix and Changes in Its Expression During the Differentiation of Human Neuroblastoma Induced by Retinoic Acid[J],2010.
APA	Shi, Song-Lin.,石松林.,Liang, Ying.,梁盈.,Li, Qi-Fu.,...&Wu, Fu-Yun.(2010).Localization of Nucleophosmin in Nuclear Matrix and Changes in Its Expression During the Differentiation of Human Neuroblastoma Induced by Retinoic Acid..
MLA	Shi, Song-Lin,et al."Localization of Nucleophosmin in Nuclear Matrix and Changes in Its Expression During the Differentiation of Human Neuroblastoma Induced by Retinoic Acid".(2010).

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