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	Statins Enhance Formation of Phagocyte Extracellular Traps
	Wang YM(王艺明)
	2010
关键词	STAPHYLOCOCCUS-AUREUS PNEUMONIA GROUP-A STREPTOCOCCUS IMPROVES SURVIVAL MURINE MODEL CELL-DEATH SEPSIS SIMVASTATIN MICE MACROPHAGES PRAVASTATIN
英文摘要	Statins are inhibitors of 3-hydroxy 3-methylglutaryl coenzyme A (HMG-CoA) reductase, the rate-limiting enzyme in cholesterol biosynthesis. Recent clinico-epidemiologic studies correlate patients receiving statin therapy with having reduced mortality associated with severe bacterial infection. Investigating the effect of statins on the innate immune capacity of phagocytic cells against the human pathogen Staphylococcus aureus, we uncovered a beneficial effect of statins on bacterial clearance by phagocytes, although, paradoxically, both phagocytosis and oxidative burst were inhibited. Probing instead for an extracellular mechanism of killing, we found that statins boosted the production of antibacterial DNA-based extracellular traps (ETs) by human and murine neutrophils and also monocytes/macrophages. The effect of statins to induce phagocyte ETs was linked to sterol pathway inhibition. We conclude that a drug therapy taken chronically by millions alters the functional behavior of phagocytic cells, which could have ramifications for susceptibility and response to bacterial infections in these patients.
语种	英语
内容类型	期刊论文
源URL	[http://dspace.xmu.edu.cn/handle/2288/64889]
专题	经济学院－已发表论文
推荐引用方式 GB/T 7714	Wang YM. Statins Enhance Formation of Phagocyte Extracellular Traps[J],2010.
APA	王艺明.(2010).Statins Enhance Formation of Phagocyte Extracellular Traps..
MLA	王艺明."Statins Enhance Formation of Phagocyte Extracellular Traps".(2010).

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