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	NMR分析胶质瘤细胞系CHG5和U87的代谢轮廓; Metabolic Profiles of CHG5 and U87 Glioma Cell Lines Derived by ~1H NMR
	邵巍 ; 顾金苹 ; 黄彩华 ; 黄子成 ; 季天海 ; 林东海
	2014-03-05
关键词	核磁共振(NMR) 代谢轮廓 差异性代谢物 胶质瘤细胞 恶性程度 1H NMR metabolic profile metabolite glioma cell lines malignant features
英文摘要	胶质瘤是中枢神经系统最常见的恶性肿瘤,其发病原因和恶性进展机制均不明确,给胶质瘤的临床诊疗带来很大困难.胶质瘤恶性进展伴随着癌细胞代谢改变,但可以反映胶质瘤恶性进展的代谢物信息和分子机制目前仍不清楚.该研究以两种不同恶性程度的胶质瘤细胞系CHg5和u87为研究对象,用基于nMr的代谢组学方法分析这两种胶质瘤细胞系的代谢轮廓,寻找差异性代谢物.结果表明CHg5和u87的代谢轮廓存在明显差异.在高恶性程度的u87细胞中,柠檬酸盐(CITrATE)等15种代谢物有上升趋势;而乳酸盐(lACTATE)、牛磺酸(TAurInE)等6种代谢物有下降趋势.以上结果表明这些差异性代谢物可能与胶质瘤细胞的恶性特性密切相关.这些从胶质瘤细胞系获取的代谢信息将成为临床标本代谢组学研究的重要前提和有益补充.; Gliomas are the most common malignant tumors.The lack of detailed information on the progression of gliomas make their clinical diagnosis and treatment a challenging endeavor.In this study, the metabolic profiles of two glioma cell lines(i.e., CHG5 and U87) with different malignancy were analyzed by 1H NMR.The results showed that there were significant differences in the metabolic profiles of these two cell lines.High levels of 15 metabolites including citratate, and lower levels of 6 metabolites including lactate and taurine were found in the CHG5 cell line, compared to the U87 cell line.The findings of this study suggested that metabolic profiles of glioma cell lines could be associated with their malignant features, thus may potentially be used as a measure in elucidating the molecular mechanisms underlying the progression of gliomas and in the development of non-invasive markers for monitoring of gliomas.; 厦门市科技计划社会发展资助项目(3502Z20124019;3502Z20104015); 福建省自然科学基金青年创新资助项目(2012D057)
语种	zh_CN
内容类型	期刊论文
源URL	[http://dspace.xmu.edu.cn/handle/2288/106927]
专题	化学化工－已发表论文
推荐引用方式 GB/T 7714	邵巍,顾金苹,黄彩华,等. NMR分析胶质瘤细胞系CHG5和U87的代谢轮廓, Metabolic Profiles of CHG5 and U87 Glioma Cell Lines Derived by ~1H NMR[J],2014.
APA	邵巍,顾金苹,黄彩华,黄子成,季天海,&林东海.(2014).NMR分析胶质瘤细胞系CHG5和U87的代谢轮廓..
MLA	邵巍,et al."NMR分析胶质瘤细胞系CHG5和U87的代谢轮廓".(2014).

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