In Vitro and in Vivo Studies on the Transport of PEGylated Silica Nanoparticles across the Blood-Brain Barrier

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	In Vitro and in Vivo Studies on the Transport of PEGylated Silica Nanoparticles across the Blood-Brain Barrier
	Liu, Dan ; Lin, Bingqian ; Shao, Wei ; Zhu, Zhi ; Ji, Tianhai ; Yang, Chaoyong ; Shao W(邵巍) ; Zhu Z(朱志) ; Yang CY(杨朝勇)
刊名	http://dx.doi.org/10.1021/am405219u
	2014-02-12
关键词	MICROVESSEL ENDOTHELIAL-CELLS DRUG-DELIVERY PARTICLE-SIZE PROTEIN BIODISTRIBUTION MICROPARTICLES NANOTECHNOLOGY TRANSCYTOSIS NANOCARRIERS PERMEABILITY
英文摘要	National Basic Research Program of China [81101904, 21205100, 21275122]; 973 Program of China [2010CB732402, 2013CB933703]; National Instrumentation Program [2011YQ03012412]; Transport of PEGylated silica nanoparticles (PSiNPs) with diameters of 100, 50, and 25 nm across the blood-brain barrier (BBB) was evaluated using an in vitro BBB model based on mouse cerebral endothelial cells (bEnd.3) cultured on transwell inserts within a chamber. In vivo animal experiments were further performed by noninvasive in vivo imaging and ex vivo optical imaging after injection via carotid artery. Confocal fluorescence studies were carried out to evaluate the uptake of PSiNPs by brain endothelial cells. The results showed that PSiNPs can traverse the BBB in vitro and in vivo. The transport efficiency of PSiNPs across BBB was found to be size-dependent, with increased particle size resulting in decreased efficiency. This work points to the potential application of small sized silica nanoparticles in brain imaging or drug delivery.
语种	英语
出版者	AMER CHEMICAL SOC
内容类型	期刊论文
源URL	[http://dspace.xmu.edu.cn/handle/2288/89386]
专题	化学化工－已发表论文
推荐引用方式 GB/T 7714	Liu, Dan,Lin, Bingqian,Shao, Wei,et al. In Vitro and in Vivo Studies on the Transport of PEGylated Silica Nanoparticles across the Blood-Brain Barrier[J]. http://dx.doi.org/10.1021/am405219u,2014.
APA	Liu, Dan.,Lin, Bingqian.,Shao, Wei.,Zhu, Zhi.,Ji, Tianhai.,...&杨朝勇.(2014).In Vitro and in Vivo Studies on the Transport of PEGylated Silica Nanoparticles across the Blood-Brain Barrier.http://dx.doi.org/10.1021/am405219u.
MLA	Liu, Dan,et al."In Vitro and in Vivo Studies on the Transport of PEGylated Silica Nanoparticles across the Blood-Brain Barrier".http://dx.doi.org/10.1021/am405219u (2014).