Multifunctional Fe3O4@Polydopamine Core-Shell Nanocomposites for Intracellular mRNA Detection and Imaging-Guided Photothermal Therapy

CORC > 厦门大学 > 化学化工－已发表论文

	Multifunctional Fe3O4@Polydopamine Core-Shell Nanocomposites for Intracellular mRNA Detection and Imaging-Guided Photothermal Therapy
	Lin, Li-Sen ; Cong, Zhong-Xiao ; Cao, Jian-Bo ; Ke, Kai-Mei ; Peng, Qiao-Li ; Gao, Jinhao ; Yang, Huang-Hao ; Liu, Gang ; Chen, Xiaoyuan ; Gao JH(高锦豪) ; Liu G(刘刚) ; Chen XY(陈小元)
刊名	http://dx.doi.org/10.1021/nn500722y
	2014
关键词	MAGNETIC NANOPARTICLES CANCER-THERAPY LIVING CELLS IN-VIVO BREAST-CANCER NANO-FLARES IRON-OXIDE PROBES FUNCTIONALIZATION POLYDOPAMINE
英文摘要	National Basic Research Program of China [2010CB732403, 2013CB733802, 2014CB744503]; National Natural Science Foundation of China [21125524, 51273165, 81101101]; Program for Changjiang Scholars and Innovative Research Team in University [IRT1116]; Program for New Century Excellent Talents in University [NCET-13-0502]; National Science Foundation of Fujian Province [2010J06003]; Multifunctional nanocomposites have the potential to integrate sensing, diagnostic, and therapeutic functions into a single nanostructure. Herein, we synthesize Fe3O4@polydopamine core shell nanocomposites (Fe3O4@PDA NCs) through an in situ self-polymerization method. Dopamine, a melanin-like mimic of mussel adhesive proteins, can self-polymerize to form surface-adherent polydopamine (PDA) films onto a wide range of materials including Fe3O4 nanoparticles used here. In such nanocomposites, PDA provides a number of advantages, such as near-infrared absorption, high fluorescence quenching efficiency, and a surface for further functionalization with biomolecules. We demonstrate the ability of the Fe3O4@PDA NCs to act as theranostic agents for intracellular mRNA detection and multimodal imaging-guided photothermal therapy. This work would stimulate interest in the use of PDA as a useful material to construct multifunctional nanocomposites for biomedical applications.
语种	英语
出版者	AMER CHEMICAL SOC
内容类型	期刊论文
源URL	[http://dspace.xmu.edu.cn/handle/2288/89341]
专题	化学化工－已发表论文
推荐引用方式 GB/T 7714	Lin, Li-Sen,Cong, Zhong-Xiao,Cao, Jian-Bo,et al. Multifunctional Fe3O4@Polydopamine Core-Shell Nanocomposites for Intracellular mRNA Detection and Imaging-Guided Photothermal Therapy[J]. http://dx.doi.org/10.1021/nn500722y,2014.
APA	Lin, Li-Sen.,Cong, Zhong-Xiao.,Cao, Jian-Bo.,Ke, Kai-Mei.,Peng, Qiao-Li.,...&陈小元.(2014).Multifunctional Fe3O4@Polydopamine Core-Shell Nanocomposites for Intracellular mRNA Detection and Imaging-Guided Photothermal Therapy.http://dx.doi.org/10.1021/nn500722y.
MLA	Lin, Li-Sen,et al."Multifunctional Fe3O4@Polydopamine Core-Shell Nanocomposites for Intracellular mRNA Detection and Imaging-Guided Photothermal Therapy".http://dx.doi.org/10.1021/nn500722y (2014).