Tertiary amide-based Knoevenagel-type reactions: a direct, general, and chemoselective approach to enaminones | |
Huang, Pei-Qiang ; Ou, Wei ; Xiao, Kai-Jiong ; Wang, Ai-E ; Huang PQ(黄培强) ; Wang AE(王爱娥) | |
刊名 | http://dx.doi.org/10.1039/c4cc03826f |
2014-08-14 | |
关键词 | FORMAL TOTAL-SYNTHESIS N-ALKYL LACTAMS REDUCTIVE ALKYLATION SECONDARY AMIDES ELECTROPHILIC REARRANGEMENTS ENANTIOSELECTIVE SYNTHESIS INDOLIZIDINE ALKALOIDS NUCLEOPHILIC-ADDITION DIRECT TRANSFORMATION ASYMMETRIC-SYNTHESIS |
英文摘要 | National Basic Research Program (973 Program) of China [2010CB833200]; NSF of China [21332007, 20902075]; Program for Changjiang Scholars and Innovative Research Team in University (PCSIRT) of Ministry of Education, China; We report one-pot and chemoselective Knoevenagel-type reactions using highly stable amides and lactams as the electrophilic substrates. The method is based on the in situ activation of amide carbonyl with triflic anhydride and a subsequent reaction with carbanions generated in situ from carbonyl compounds. The amide-based method is an alternative to the versatile thioamide-based Eschenmoser sulfide contraction. |
语种 | 英语 |
出版者 | ROYAL SOC CHEMISTRY |
内容类型 | 期刊论文 |
源URL | [http://dspace.xmu.edu.cn/handle/2288/89234] |
专题 | 化学化工-已发表论文 |
推荐引用方式 GB/T 7714 | Huang, Pei-Qiang,Ou, Wei,Xiao, Kai-Jiong,et al. Tertiary amide-based Knoevenagel-type reactions: a direct, general, and chemoselective approach to enaminones[J]. http://dx.doi.org/10.1039/c4cc03826f,2014. |
APA | Huang, Pei-Qiang,Ou, Wei,Xiao, Kai-Jiong,Wang, Ai-E,黄培强,&王爱娥.(2014).Tertiary amide-based Knoevenagel-type reactions: a direct, general, and chemoselective approach to enaminones.http://dx.doi.org/10.1039/c4cc03826f. |
MLA | Huang, Pei-Qiang,et al."Tertiary amide-based Knoevenagel-type reactions: a direct, general, and chemoselective approach to enaminones".http://dx.doi.org/10.1039/c4cc03826f (2014). |
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