Asymmetric Catalysis with an Inert Chiral-at-Metal Iridium Complex

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	Asymmetric Catalysis with an Inert Chiral-at-Metal Iridium Complex
	Chen, Liang-An ; Xu, Weici ; Huang, Biao ; Ma, Jiajia ; Wang, Lun ; Xi, Jianwei ; Harms, Klaus ; Gong, Lei ; Meggers, Eric ; Gong L(龚磊) ; ERIC MEGGERS
刊名	http://dx.doi.org/10.1021/ja403777k
	2013
关键词	HIGHLY ENANTIOSELECTIVE HYDROGENATION FRIEDEL-CRAFTS ALKYLATION BOND DONORS CHELATING DIPHOSPHINES ALKENE HYDROGENATIONS ALLYLIC SUBSTITUTION CONJUGATE REDUCTION ACHIRAL LIGANDS ORGANOCATALYSIS NITROALKENES
英文摘要	National Natural Science Foundation of China [21272192, 21201143]; Program for Changjiang Scholars and Innovative Research Team of the University (PCSIRT); National Thousand Plan Foundation of China; 985 Program of the Chemistry and Chemical Engineering Disciplines of Xiamen University; The development of a chiral-at-metal iridium(III) complex for the highly efficient catalytic asymmetric transfer hydrogenation of beta,beta'-disubstituted nitroalkenes is reported. Catalysis by this inert, rigid metal complex does not involve any direct metal coordination but operates exclusively through weak interactions with functional groups properly arranged in the ligand sphere of the iridium complex. Although the iridium complex relies only on the formation of three hydrogen bonds, it exceeds the performance of most organocatalysts with respect to enantiomeric excess (up to 99% ee) and catalyst loading (down to 0.1 mol %). This work hints at an advantage of structurally complicated rigid scaffolds for non-covalent catalysis, which especially relies on conformationally constrained cooperative interactions between the catalyst and substrates.
语种	英语
出版者	AMER CHEMICAL SOC
内容类型	期刊论文
源URL	[http://dspace.xmu.edu.cn/handle/2288/88929]
专题	化学化工－已发表论文
推荐引用方式 GB/T 7714	Chen, Liang-An,Xu, Weici,Huang, Biao,et al. Asymmetric Catalysis with an Inert Chiral-at-Metal Iridium Complex[J]. http://dx.doi.org/10.1021/ja403777k,2013.
APA	Chen, Liang-An.,Xu, Weici.,Huang, Biao.,Ma, Jiajia.,Wang, Lun.,...&ERIC MEGGERS.(2013).Asymmetric Catalysis with an Inert Chiral-at-Metal Iridium Complex.http://dx.doi.org/10.1021/ja403777k.
MLA	Chen, Liang-An,et al."Asymmetric Catalysis with an Inert Chiral-at-Metal Iridium Complex".http://dx.doi.org/10.1021/ja403777k (2013).