Antiproliferative Cardiac Glycosides from the Latex of Antiaris toxicaria

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	Antiproliferative Cardiac Glycosides from the Latex of Antiaris toxicaria
	Liu, Qian ; Tang, Jin-Shan ; Hu, Meng-Jie ; Liu, Jie ; Chen, Hai-Feng ; Gao, Hao ; Wang, Guang-Hui ; Li, Shun-Lin ; Hao, Xiao-Jiang ; Zhang, Xiao-Kun ; Yao, Xin-Sheng ; Liu J(刘婕) ; Chen HF(陈海峰) ; Wang GH(王光辉) ; Zhang XK(张晓坤)
刊名	http://dx.doi.org/10.1021/np4005147
	2013
关键词	GLYKOSIDE UND AGLYKONE DART-POISON LESCH CARDENOLIDES CELLS
英文摘要	National Natural Science Foundation of China [81001373, 91129302]; State Key Laboratory of Phytochemistry and Plant Resources in West China [P2010-KF04]; Phytochemical investigation of the latex of Antiaris toxicaria resulted in the isolation of 15 new [antiarosides J-X (1-15)] and 17 known cardiac glycosides. The effects of the cardiac glycosides on apoptosis and the expression of orphan nuclear receptor Nur77 were examined in human NIH-H460 lung cancer cells. Several of the cardiac glycosides induced apoptosis in lung cancer cells, which was accompanied by induction of Nur77 protein expression. Treatment of cancer cells with the cardiac glycosides resulted in translocation of the Nur77 protein from the nucleus to the cytoplasm and subsequent targeting to mitochondria. The results show that the cardiac glycosides exert their apoptotic effect through the Nur77-dependent apoptotic pathway.
语种	英语
出版者	AMER CHEMICAL SOC
内容类型	期刊论文
源URL	[http://dspace.xmu.edu.cn/handle/2288/88914]
专题	化学化工－已发表论文
推荐引用方式 GB/T 7714	Liu, Qian,Tang, Jin-Shan,Hu, Meng-Jie,et al. Antiproliferative Cardiac Glycosides from the Latex of Antiaris toxicaria[J]. http://dx.doi.org/10.1021/np4005147,2013.
APA	Liu, Qian.,Tang, Jin-Shan.,Hu, Meng-Jie.,Liu, Jie.,Chen, Hai-Feng.,...&张晓坤.(2013).Antiproliferative Cardiac Glycosides from the Latex of Antiaris toxicaria.http://dx.doi.org/10.1021/np4005147.
MLA	Liu, Qian,et al."Antiproliferative Cardiac Glycosides from the Latex of Antiaris toxicaria".http://dx.doi.org/10.1021/np4005147 (2013).