Chemical interactions of mercury species and some transition and noble metals towards metallothionein (Zn7MT-2) evaluated using SEC/ICP-MS, RP-HPLC/ESI-MS and MALDI-TOF-MS

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	Chemical interactions of mercury species and some transition and noble metals towards metallothionein (Zn7MT-2) evaluated using SEC/ICP-MS, RP-HPLC/ESI-MS and MALDI-TOF-MS
	Xu, Ming ; Yang, Limin ; Wang, Qiuquan ; Yang LM(杨利民) ; Wang QQ(王秋泉)
刊名	http://dx.doi.org/10.1039/c3mt00016h
	2013
关键词	MASS-SPECTROMETRY ICP-MS BINDING IDENTIFICATION PROTEINS MECHANISM TOXICITY PEPTIDE LIVER MICE
英文摘要	National Natural Science Foundation of China [21035006, 21275120]; National Basic Research Program 973 Project [2009CB421605]; The chemical affinities of three submetallomes ("Mn, Co, Ni, Cu, Cd''; "Pd, Pt, Au''; and "Hg, CH3Hg, C2H5Hg-THI'') towards metallothionein-2 (Zn7MT-2) in a physiological solution environment were evaluated using SEC/ICP-MS together with RP-HPLC/ESI-IT-MS and MALDI-TOF-MS, and followed the order: "Zn2+ < Cu2+, Cd2+ > Ni2+ > Mn2+, Co2+''; "Pd2+ > Au3+ > Pt2+''; and "Hg2+ > CH3Hg+ > C2H5Hg-THI''. Besides these, the structural change and composition of the CH3Hg-MT-2 complexes formed during the CH3Hg+ titration process were further investigated using CD spectroscopy, RP-HPLC/ESI-MS and MALDI-TOF-MS, indicating that linear and more hydrophobic (CH3Hg)(x)MT-2 (x = 12, 13, 14, 15, 16, 17, 18, 19 and 20) were formed. This information is important in understanding the interactions of the metals with Zn7MT-2 and their corresponding biological functions and toxicities.
语种	英语
出版者	ROYAL SOC CHEMISTRY
内容类型	期刊论文
源URL	[http://dspace.xmu.edu.cn/handle/2288/88761]
专题	化学化工－已发表论文
推荐引用方式 GB/T 7714	Xu, Ming,Yang, Limin,Wang, Qiuquan,et al. Chemical interactions of mercury species and some transition and noble metals towards metallothionein (Zn7MT-2) evaluated using SEC/ICP-MS, RP-HPLC/ESI-MS and MALDI-TOF-MS[J]. http://dx.doi.org/10.1039/c3mt00016h,2013.
APA	Xu, Ming,Yang, Limin,Wang, Qiuquan,杨利民,&王秋泉.(2013).Chemical interactions of mercury species and some transition and noble metals towards metallothionein (Zn7MT-2) evaluated using SEC/ICP-MS, RP-HPLC/ESI-MS and MALDI-TOF-MS.http://dx.doi.org/10.1039/c3mt00016h.
MLA	Xu, Ming,et al."Chemical interactions of mercury species and some transition and noble metals towards metallothionein (Zn7MT-2) evaluated using SEC/ICP-MS, RP-HPLC/ESI-MS and MALDI-TOF-MS".http://dx.doi.org/10.1039/c3mt00016h (2013).