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	Multifunctional ultrasmall Pd nanosheets for enhanced near-infrared photothermal therapy and chemotherapy of cancer
	Shaoheng Tang ; Tang SH(汤少恒) ; Mei Chen ; Chen M(陈美) ; Nanfeng Zheng ; Zheng NF(郑南峰)
	2015-01
关键词	photothermal therapy chemotherapy Pd nanosheets drug delivery synergistic effect
英文摘要	通讯作者地址: Zheng, NF 电子邮件地址:nfzheng@xmu.edu.cn; Near-infrared (NIR) photothermal therapy has developed very quickly in recent years. However, its clinical applications are hindered by many practical problems, such as low accumulation in tumors, high laser power density and high biotoxicity in vivo. Herein, a versatile system combining chemotherapy with photothermal therapy for cancer therapy using ultrasmall Pd nanosheets (SPNS) has been developed. The SPNS can serve as pH-responsive drug carriers to efficiently deliver DOX into cancer cells and tumors. On the other hand, the coordinative loading of DOX on SPNS enhances its accumulation in tumor tissue. So we can efficiently ablate tumor using low-intensity laser radiation. Importantly, with ultrasmall size (similar to 4.4 nm), SPNS surface-functionalized with reduced glutathione (GSH) can be cleared from the body through the renal system into the urine. This cancer therapeutic nanosystem, which exhibits a significant synergistic effect and low systemic toxicity, has great potential for clinical applications.; Ministry of Science and Technology of China 2011CB932403 2014CB932004 National Natural Science Foundation of China 21131005
语种	英语
出版者	TSINGHUA UNIV PRESS
内容类型	期刊论文
源URL	[http://dspace.xmu.edu.cn/handle/2288/84890]
专题	化学化工－已发表论文
推荐引用方式 GB/T 7714	Shaoheng Tang,Tang SH,Mei Chen,et al. Multifunctional ultrasmall Pd nanosheets for enhanced near-infrared photothermal therapy and chemotherapy of cancer[J],2015.
APA	Shaoheng Tang,汤少恒,Mei Chen,陈美,Nanfeng Zheng,&郑南峰.(2015).Multifunctional ultrasmall Pd nanosheets for enhanced near-infrared photothermal therapy and chemotherapy of cancer..
MLA	Shaoheng Tang,et al."Multifunctional ultrasmall Pd nanosheets for enhanced near-infrared photothermal therapy and chemotherapy of cancer".(2015).

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