Pd Nanosheet-Covered Hollow Mesoporous Silica Nanoparticles as a Platform for the Chemo-Photothermal Treatment of Cancer Cells

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	Pd Nanosheet-Covered Hollow Mesoporous Silica Nanoparticles as a Platform for the Chemo-Photothermal Treatment of Cancer Cells
	Fang, Weijun ; Tang, Shaoheng ; Liu, Pengxin ; Fang, Xiaoliang ; Gong, Jiawei ; Zheng, Nanfeng ; Zheng NF(郑南峰)
刊名	http://dx.doi.org/10.1002/smll.201200962
	2012-12-21
关键词	WALLED CARBON NANOTUBES MULTIFUNCTIONAL NANOPARTICLES GOLD NANOPARTICLES GRAPHENE OXIDE DRUG-DELIVERY THERAPY ABLATION NANOCRYSTALS RELEASE NANORODS
英文摘要	MOST of China [2011CB932403]; NSFC [21131005, 21021061, 20925103]; NSF of Fujian Province [2009J06005]; Fok Ying Tung Education Foundation [121011]; NFFTBS [J1030415]; A versatile system combining chemotherapy with photothermal therapy for cancer cells using Pd nanosheet-covered hollow mesoporous silica nanoparticles is reported. While the hollow mesoporous silica core can be used to load anticancer drugs (i.e., doxorubicin) for chemotherapy, the Pd nanosheets on the surface of particles can convert NIR light into heat for photothermal therapy. More importantly, the loading of Pd nanosheets on hollow mesoporous silica nanospheres can dramatically increase the amount of cellular internalization of the Pd nanosheets: almost 11 times higher than the unloaded Pd nanosheets. The as-prepared nanocomposites efficiently deliver both drugs and heat to cancer cells to improve the therapeutic efficiency with minimal side effects. Compared with chemotherapy or photothermal therapy alone, the combination of chemotherapy and phototherapy can significantly improve the therapeutic efficacy, exhibiting a synergistic effect.
语种	英语
内容类型	期刊论文
源URL	[http://dspace.xmu.edu.cn/handle/2288/64010]
专题	化学化工－已发表论文
推荐引用方式 GB/T 7714	Fang, Weijun,Tang, Shaoheng,Liu, Pengxin,et al. Pd Nanosheet-Covered Hollow Mesoporous Silica Nanoparticles as a Platform for the Chemo-Photothermal Treatment of Cancer Cells[J]. http://dx.doi.org/10.1002/smll.201200962,2012.
APA	Fang, Weijun.,Tang, Shaoheng.,Liu, Pengxin.,Fang, Xiaoliang.,Gong, Jiawei.,...&郑南峰.(2012).Pd Nanosheet-Covered Hollow Mesoporous Silica Nanoparticles as a Platform for the Chemo-Photothermal Treatment of Cancer Cells.http://dx.doi.org/10.1002/smll.201200962.
MLA	Fang, Weijun,et al."Pd Nanosheet-Covered Hollow Mesoporous Silica Nanoparticles as a Platform for the Chemo-Photothermal Treatment of Cancer Cells".http://dx.doi.org/10.1002/smll.201200962 (2012).