A new strategy for basic drug extraction in aqueous medium using electrochemically enhanced solid-phase microextraction

CORC > 厦门大学 > 化学化工－已发表论文

	A new strategy for basic drug extraction in aqueous medium using electrochemically enhanced solid-phase microextraction
	Zeng, Jingbin ; Zou, Jing ; Song, Xinhong ; Chen, Jinmei ; Ji, Jiaojiao ; Wang, Bo ; Wang, Yiru ; Ha, Jaeho ; Chen, Xi ; Wang YR(王翊如)
刊名	http://dx.doi.org/10.1016/j.chroma.2010.11.020
	2011-01-14
关键词	MULTIWALLED CARBON NANOTUBES GAS-CHROMATOGRAPHY SAMPLE PREPARATION MASS SPECTROMETRY WASTE-WATER HUMAN HAIR URINE
英文摘要	Science and Technology Projects of Fujian Province [2010Y0050]; Program of Science and Technology of Xiamen for University Innovation [3502Z20093004]; National Nature Scientific Foundation of China-Korea [20911140274]; NFFTBS [J1030415]; This work describes an electrochemically enhanced solid-phase microextraction (EE-SPME) method using a mild negative potential (-0.6 V) for the enhanced extraction of the selected basic drugs in a pure aqueous matrix and urine samples. The EE-SPME method gave a more effective extraction of drugs (primarily via electrophoresis and complementary charge interaction) compared to that obtained with SPME (without applying a potential, and which is based on passive partitioning). The EE-SPME method eliminated the need for alkalizing, derivatizing the drugs, or modifying the fiber coating before extraction. The analysis of methamphetamine (MA) and amphetamine (AM) was selected as a typical example to demonstrate in detail the advantages of EE-SPME over SPME. Based on the results obtained, 3-min extraction efficiency for both the amphetamines using EE-SPME was better than that of 30-min using SPME. The developed EE-SPME-GC method exhibited wide linear ranges (2-1000 ng mL(-1)) for both the amphetamines with R(2) larger than 0.99, and the method detection limits (MDLs) for AM and MA were 0.26 and 0.12 ng mL(-1), respectively. In addition, the EE-SPME method developed was also successfully applied to enhance the extraction of several other basic drugs (ephedrine, 3,4-methylenedioxyamphetamine (MDA), atropine, methadone, cocaine, codeine, acetylcodeine and papaverine) with preconcentration factors from 157 to 2199, indicating the potential applicability of this method in the field of forensic, clinical and pharmaceutical analysis. (C) 2010 Elsevier B.V. All rights reserved.
语种	英语
内容类型	期刊论文
源URL	[http://dspace.xmu.edu.cn/handle/2288/62801]
专题	化学化工－已发表论文
推荐引用方式 GB/T 7714	Zeng, Jingbin,Zou, Jing,Song, Xinhong,et al. A new strategy for basic drug extraction in aqueous medium using electrochemically enhanced solid-phase microextraction[J]. http://dx.doi.org/10.1016/j.chroma.2010.11.020,2011.
APA	Zeng, Jingbin.,Zou, Jing.,Song, Xinhong.,Chen, Jinmei.,Ji, Jiaojiao.,...&王翊如.(2011).A new strategy for basic drug extraction in aqueous medium using electrochemically enhanced solid-phase microextraction.http://dx.doi.org/10.1016/j.chroma.2010.11.020.
MLA	Zeng, Jingbin,et al."A new strategy for basic drug extraction in aqueous medium using electrochemically enhanced solid-phase microextraction".http://dx.doi.org/10.1016/j.chroma.2010.11.020 (2011).