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	NMR-based Metabolomic Analysis of Human Bladder Cancer
	Cao, Ming ; Zhao, Liangcai ; Chen, Haige ; Xue, Wei ; Lin, Donghai ; Lin DH(林东海)
	2012-05
关键词	CELL CARCINOMA PLASMA TYROSINE STROMA SERUM H-1 PHENYLALANINE SPECTROSCOPY SPECTROMETRY METABONOMICS
英文摘要	Bladder cancer (BC) is one of the most common cancers and has a high mortality rate. However, both metabolite variations and metabolic pathways related to the pathogenic process of BC remain to be addressed, such results might contribute to early detection of the disease. H-1 nuclear magnetic resonance (NMR)-based metabolomics was applied to identify differences of serum metabolic profiles among BC, calculi patients and healthy subjects. Serum metabolic profiles of BC patients are distinctly different from those of calculi and healthy subjects. Compared with those from healthy subjects, serum samples from BC patients show decreased levels of isoleucine/leucine, tyrosine, lactate, glycine, citrate, as well as increased levels of lipids and glucose. The results reveal disturbed metabolic pathways of aromatic amino acids, glycolysis and citrate cycle, as well as lipogenesis metabolism in BC patients. Our work will be of potential benefit to understanding the pathogenic process of BC and will offer valuable information for noninvasive diagnosis of the disease.; National Natural Science Foundation of China [81100598, 91129713, 31170717]; Program of Shanghai Subject Chief Scientist [09XD1405100]
语种	英语
出版者	JAPAN SOC ANALYTICAL CHEMISTRY
内容类型	期刊论文
源URL	[http://dspace.xmu.edu.cn/handle/2288/15486]
专题	化学化工－已发表论文
推荐引用方式 GB/T 7714	Cao, Ming,Zhao, Liangcai,Chen, Haige,et al. NMR-based Metabolomic Analysis of Human Bladder Cancer[J],2012.
APA	Cao, Ming,Zhao, Liangcai,Chen, Haige,Xue, Wei,Lin, Donghai,&林东海.(2012).NMR-based Metabolomic Analysis of Human Bladder Cancer..
MLA	Cao, Ming,et al."NMR-based Metabolomic Analysis of Human Bladder Cancer".(2012).

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