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	Further insights into hydrophobic interactions between ferrocenyl-tamoxifen drugs and non-polar molecular architectures at electrode surfaces
	Mertins, Omar（Univ Paris 06, UMR CNRS PASTEUR 8640） ; Buriez, Olivier（Univ Paris 06, UMR CNRS PASTEUR 8640） ; Labbe, Eric（Univ Paris 06, UMR CNRS PASTEUR 8640） ; Fang, Ping-Ping ; Hillard, Elizabeth（Ecole Natl Super Chim Paris, CNRS） ; Vessieres, Anne（Ecole Natl Super Chim Paris, CNRS） ; Jaouen, Gerard（Ecole Natl Super Chim Paris, CNRS） ; Tian, Zhong-Qun ; Tian ZQ(田中群) ; Amatore, Christian（Univ Paris 06, UMR CNRS PASTEUR 8640）
	2009-07
关键词	Tamoxifen Ferrocene Cyclodextrin Modified electrode Breast cancer
英文摘要	The hydrophobic interactions between ferrocenyl compounds, based on the tamoxifen skeleton (ferrocifens), and non-polar molecular architectures, such as cyclodextrin (CD) cavities and unsubstituted n-alkane chains, were investigated in water and alcohol/water mixtures by cyclic voltammetry through three different approaches. In the first one, the organometallic complex was covalently attached to a glassy carbon electrode surface whereas the CD was dissolved in homogeneous solution. The second one consisted in preparing a self-assembled monolayer of a mixture of synthesized per-6-thio-beta-CD and of pentanethiol chains at a gold electrode surface, whereas the ferrocifen complex was initially present in solution. In the third approach, the gold electrode surface was modified only with alkane thiol monolayers having various lengths. As expected, the complexation between the ferrocene moiety of the tamoxifen derivative and the CD cavity became stronger as the solvent polarity increased. Interestingly, two different electrochemical behaviors could be evidenced for the neutral starting complex and for the electrogenerated cationic ferrocenium derivative owing to their different polarities. Importantly, the reduction process of the cationic complex followed a distinct behavior on adsorbed CDs and on alkane chains. Notably, the presence of two aromatic rings in the ferrocenyl structure proved to favor its facile penetration through short alkyl chains (CnH2n+1, n <= 5). For much longer chains (16 <= n < 5) a faradaic oxidation current was still observed for ferrocifen though progressively diminished. (C) 2009 Elsevier B.V. All rights reserved.; Agence Nationale de la Recherche [ANR-06-BLAN-0384-01]; NFSC ; Xiamen University ; LIA CNRS XiamENS
语种	英语
出版者	ELSEVIER SCIENCE SA\
内容类型	期刊论文
源URL	[http://dx.doi.org/doi:10.1016/j.jelechem.2009.07.015]
专题	化学化工－已发表论文
推荐引用方式 GB/T 7714	Mertins, Omar,Buriez, Olivier,Labbe, Eric,et al. Further insights into hydrophobic interactions between ferrocenyl-tamoxifen drugs and non-polar molecular architectures at electrode surfaces[J],2009.
APA	Mertins, Omar.,Buriez, Olivier.,Labbe, Eric.,Fang, Ping-Ping.,Hillard, Elizabeth.,...&Amatore, Christian.(2009).Further insights into hydrophobic interactions between ferrocenyl-tamoxifen drugs and non-polar molecular architectures at electrode surfaces..
MLA	Mertins, Omar,et al."Further insights into hydrophobic interactions between ferrocenyl-tamoxifen drugs and non-polar molecular architectures at electrode surfaces".(2009).

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