Synthesis, characterization, and temperature-responsive behaviors of novel hybrid amphiphilic block copolymers containing polyhedral oligomeric silsesquioxane

CORC > 厦门大学 > 材料学院－已发表论文

	Synthesis, characterization, and temperature-responsive behaviors of novel hybrid amphiphilic block copolymers containing polyhedral oligomeric silsesquioxane
	Xu, Yiting ; Xie, Jianjie ; Chen, Lingnan ; Gao, Hui ; Yuan, Conghui ; Li, Cong ; Luo, Weiang ; Zeng, Birong ; Dai, Lizong ; Xu YT(许一婷) ; Luo WA(罗伟昂) ; Ceng BR(曾碧榕) ; Dai LZ(戴李宗)
刊名	http://dx.doi.org/10.1002/pat.3258
	2014
关键词	Acrylic monomers Drug therapy Dynamic light scattering Ethylene glycol Hybrid materials Micelles Transmission electron microscopy
英文摘要	Organic/inorganic hybrid amphiphilic block copolymer poly(methacrylate isobutyl POSS)-b-poly(N-isopropylacrylamide-co-oligo(ethylene glycol) methyl ether methacrylate) (PMAPOSS-b-P(NIPAM-co-OEGMA)) was synthesized via reversible addition-fragmentation chain transfer polymerization. The self-assembly behavior of this block copolymer in aqueous solution was investigated by dynamic light scattering (DLS) and transmission electron microscopy. The results indicate that the novel block copolymer can self-assemble into spherical micelles with PMAPOSS segment as the hydrophobic part and P(NIPAM-co-OEGMA) segment as the hydrophilic part. The temperature-responsive characteristics of the assemblies were tested by UV-Vis spectra and DLS. Some factors such as the concentration, molecular weight, and copolymer generation that may affect the cloud point were studied systematically. The results reveal that this copolymer exhibits a sharp and intensive lower critical solution temperature (LCST). The essentially predetermined LCST can be conveniently achieved by adjusting the content of NIPAM or OEGMA domain. In addition, these novel hybrid micelles can undergo an association/disassociation cycle with the heating and cooling of solution and the degree of reversibility displaying a tremendous concentration dependence, as a novel organic/inorganic hybrid material with distinctive virtues can be potentially used in biological and medical fields, especially in drug nanocarriers for targeted therapy. ? 2014 John Wiley & Sons, Ltd.
语种	英语
出版者	WILEY-BLACKWELL
内容类型	期刊论文
源URL	[http://dspace.xmu.edu.cn/handle/2288/87440]
专题	材料学院－已发表论文
推荐引用方式 GB/T 7714	Xu, Yiting,Xie, Jianjie,Chen, Lingnan,et al. Synthesis, characterization, and temperature-responsive behaviors of novel hybrid amphiphilic block copolymers containing polyhedral oligomeric silsesquioxane[J]. http://dx.doi.org/10.1002/pat.3258,2014.
APA	Xu, Yiting.,Xie, Jianjie.,Chen, Lingnan.,Gao, Hui.,Yuan, Conghui.,...&戴李宗.(2014).Synthesis, characterization, and temperature-responsive behaviors of novel hybrid amphiphilic block copolymers containing polyhedral oligomeric silsesquioxane.http://dx.doi.org/10.1002/pat.3258.
MLA	Xu, Yiting,et al."Synthesis, characterization, and temperature-responsive behaviors of novel hybrid amphiphilic block copolymers containing polyhedral oligomeric silsesquioxane".http://dx.doi.org/10.1002/pat.3258 (2014).