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	Microwave-assisted synthesis of poly(epsilon-caprolactone) with acid as initiator and a novel method in preparation of drug release systems
	Song, Y. ; Liu, L. J. ; Yu, Z. J. ; Weng, X. C. ; Zhuo, R. X. ; Yu ZJ(余兆菊)
	2003
英文摘要	Acid-initiated ring-opening polymerization (ROP) of epsilon-caprolactone (epsilon-CL) was performed under microwave irradiation without metallic catalysts. Poly(epsilon-caprolactone) (PCL) with weight-average molar mass (Mw) over 12000 g/mol and Mw/Mn below 1.6 was synthesized in the presence of carboxylic acids such as maleic acid (MA), succinic acid and adipic acid. The effects of microwave power, irradiation time, epsilon-CL/acid molar ratio and acidity of acid on the polymerization were investigated. Both the rate of polymerization and molar mass of the obtained polymer were enhanced in comparison with conventional thermal method. As a new treatment, PCL-based drug controlled release system was obtained directly by microwave-assisted ROP of epsilon-CL mixed with ibuprofen (IBU) initiated by MA. The release of IBU from the system was sustained from 12 h to 9 days with IBU content in weight from 5 to 20%. It seems that this is a promising method to prepare drug controlled release systems.
语种	英语
内容类型	期刊论文
源URL	[http://dspace.xmu.edu.cn/handle/2288/59022]
专题	材料学院－已发表论文
推荐引用方式 GB/T 7714	Song, Y.,Liu, L. J.,Yu, Z. J.,et al. Microwave-assisted synthesis of poly(epsilon-caprolactone) with acid as initiator and a novel method in preparation of drug release systems[J],2003.
APA	Song, Y.,Liu, L. J.,Yu, Z. J.,Weng, X. C.,Zhuo, R. X.,&余兆菊.(2003).Microwave-assisted synthesis of poly(epsilon-caprolactone) with acid as initiator and a novel method in preparation of drug release systems..
MLA	Song, Y.,et al."Microwave-assisted synthesis of poly(epsilon-caprolactone) with acid as initiator and a novel method in preparation of drug release systems".(2003).

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