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	急性缺血性脑卒中患者血清脂蛋白(a)水平及临床意义
	贾淑芬 ; 李洪利 ; JIA Shu-fen ; LI Hong-li
	2016-03-30 ; 2016-03-30
关键词	脑卒中 急性 缺血 脂蛋白(a) 短期 预后 Gastrointestinal disorder Thinking bias Perceived health R743.3
其他题名	Significance of Serum Lipoprotein(a) in Patients with Acute Ischemic Stroke
中文摘要	目的研究急性缺血性脑卒中患者血清脂蛋白(a)水平及其与短期预后的关系。方法检测210例急性缺血性脑卒中患者以及100名性别和年龄匹配的健康人血清脂蛋白(a)水平。患者入院后行美国国立卫生研究院卒中量表(NIHSS)评定。出院时行改良Rankin量表(m RS)评定。结果患者组血清脂蛋白(a)水平显著高于健康人(P<0.001)。调整其他危险因素后,血清脂蛋白(a)水平是m RS的独立预测因素(P<0.001)。接受者操作特征曲线下面积分析,脂蛋白(a)和NIHSS联合模型的预测准确度高于NIHSS评分。结论急性缺血性脑卒中患者血清脂蛋白(a)水平升高。血清脂蛋白(a)水平是急性缺血性脑卒中短期预后的独立预测因素。; Objective To investigate the serum lipoprotein(Lp)(a) level in patients with acute ischemic stroke and the prediction for short-term functional outcome. Methods The levels of serum Lp(a) were measured in 210 patients with acute ischemic stroke(within 24 h after onset) and 100 healthy people matched the gender and age. The patients were assessed with National Institutes of Health Stroke Scale(NIHSS) as admission, and modified Rankin Scale(m RS) as discharge. Results The median of Lp(a) was 325 mg/L(IQR: 180~545) in patients, significantly more than 148 mg/L(IQR: 69~265) in the normal controls(P<0.001). Level of serum Lp(a) was an independent variable for functional outcome(OR=1.004, 95%CI: 1.001~1.007, P<0.001) and death(OR=1.006, 95%CI: 1.001~1.008, P<0.001) in patients. In the receiver operating characteristic curve, the area under curve was more in the combined model [Lp(a) and NIHSS] than the NIHSS alone.Conclusion Serum Lp(a) increased in the in patients with acute ischemic stroke, and may predict the short-term outcome independently.
语种	中文 ; 中文
内容类型	期刊论文
源URL	[http://ir.lib.tsinghua.edu.cn/ir/item.do?handle=123456789/147405]
专题	清华大学
推荐引用方式 GB/T 7714	贾淑芬,李洪利,JIA Shu-fen,等. 急性缺血性脑卒中患者血清脂蛋白(a)水平及临床意义[J],2016, 2016.
APA	贾淑芬,李洪利,JIA Shu-fen,&LI Hong-li.(2016).急性缺血性脑卒中患者血清脂蛋白(a)水平及临床意义..
MLA	贾淑芬,et al."急性缺血性脑卒中患者血清脂蛋白(a)水平及临床意义".(2016).

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