Facile Fabrication of Aggregation-induced Emission Based Red Fluorescent Organic Nanoparticles for Cell Imaging | |
Zhang XQ(张锡奇) ; Xiao-yong Zhang ; Bin Yang ; Wei Y(危岩) ; Xi-qi Zhang ; Xiao-yong Zhang ; Bin Yang ; Yan Wei | |
2016-03-30 ; 2016-03-30 | |
关键词 | Cyano-substituted diarylethlene derivative Aggregation-induced emission Anhydride ring-opening polymerization Red fluorescent organic nanoparticles Cell imaging. TQ422 |
其他题名 | Facile Fabrication of Aggregation-induced Emission Based Red Fluorescent Organic Nanoparticles for Cell Imaging |
中文摘要 | A cyano-substituted diarylethlene derivative aggregation-induced emission(AIE) dye with two amino end-groups and 4,4'-(hexafluoroisopropylidene)diphthalic anhydride were facilely incorporated into red fluorescent organic nanoparticles(FONs) via room temperature anhydride ring-opening polymerization under an air atmosphere. These obtained RO-HFDA FONs were characterized by a series of techniques including gel permeation chromatography, Fourier transform infrared spectroscopy, size distribution and zeta potential measurements, UV-Vis absorption spectrum, fluorescent spectroscopy and transmission electron microscopy. Biocompatibility evaluation and cell uptake behavior of RO-HFDA FONs were further investigated to explore their potential biomedical application. We demonstrated that such FONs showed high water dispersibility, stable uniform spherical morphology(150-200 nm), broad excitation band(350-605 nm), intense red fluorescence(627 nm) and excellent biocompatibility, making them promising for cell imaging applications.; A cyano-substituted diarylethlene derivative aggregation-induced emission(AIE) dye with two amino end-groups and 4,4'-(hexafluoroisopropylidene)diphthalic anhydride were facilely incorporated into red fluorescent organic nanoparticles(FONs) via room temperature anhydride ring-opening polymerization under an air atmosphere. These obtained RO-HFDA FONs were characterized by a series of techniques including gel permeation chromatography, Fourier transform infrared spectroscopy, size distribution and zeta potential measurements, UV-Vis absorption spectrum, fluorescent spectroscopy and transmission electron microscopy. Biocompatibility evaluation and cell uptake behavior of RO-HFDA FONs were further investigated to explore their potential biomedical application. We demonstrated that such FONs showed high water dispersibility, stable uniform spherical morphology(150-200 nm), broad excitation band(350-605 nm), intense red fluorescence(627 nm) and excellent biocompatibility, making them promising for cell imaging applications. |
语种 | 英语 ; 英语 |
内容类型 | 期刊论文 |
源URL | [http://ir.lib.tsinghua.edu.cn/ir/item.do?handle=123456789/145911] |
专题 | 清华大学 |
推荐引用方式 GB/T 7714 | Zhang XQ,Xiao-yong Zhang,Bin Yang,et al. Facile Fabrication of Aggregation-induced Emission Based Red Fluorescent Organic Nanoparticles for Cell Imaging[J],2016, 2016. |
APA | 张锡奇.,Xiao-yong Zhang.,Bin Yang.,危岩.,Xi-qi Zhang.,...&Yan Wei.(2016).Facile Fabrication of Aggregation-induced Emission Based Red Fluorescent Organic Nanoparticles for Cell Imaging.. |
MLA | 张锡奇,et al."Facile Fabrication of Aggregation-induced Emission Based Red Fluorescent Organic Nanoparticles for Cell Imaging".(2016). |
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