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	Endogenously generated amyloid beta increases membrane fluidity in neural 2a cells
	Niu Ying ; Sheng BaiYang ; Song Bo ; Liu LingLing ; Zhang XiuFang ; Zhao NanMing ; Gong YanDao
	2010-10-12 ; 2010-10-12
关键词	membrane fluidity fluorescence polarizability Alzheimer's disease amyloid beta ALZHEIMERS-DISEASE ION CHANNELS ZN2+-SENSITIVE CHANNEL PEPTIDE OLIGOMERS TERMINUS Multidisciplinary Sciences
中文摘要	The effect of endogenously generated amyloid beta on membrane fluidity was investigated in Neural 2a cells stably expressing Swedish mutant amyloid precursor protein (APPswe). Membrane fluidity was studied by fluorescence polarizability using 1,6-Diphenyl-1,3,5-Hexatriene (DPH) as the fluorescence probe. It was found that the membrane fluidity in APPswe cells was significantly higher than that in its wild type counterparts. Alleviating the effect of amyloid beta either by gamma secretase activity inhibition or by amyloid antibody treatment decreased membrane fluidity, which indicated an important role of amyloid beta in increasing membrane fluidity. Treatment using amyloid beta channel blocker, tromethamine and NA4 suggested that channel formed by amyloid beta on the cell membrane is a way through which amyloid beta takes its membrane fluidizing effect.
语种	英语 ; 英语
出版者	SCIENCE CHINA PRESS ; BEIJING ; 16 DONGHUANGCHENGGEN NORTH ST, BEIJING 100717, PEOPLES R CHINA
内容类型	期刊论文
源URL	[http://hdl.handle.net/123456789/81898]
专题	清华大学
推荐引用方式 GB/T 7714	Niu Ying,Sheng BaiYang,Song Bo,et al. Endogenously generated amyloid beta increases membrane fluidity in neural 2a cells[J],2010, 2010.
APA	Niu Ying.,Sheng BaiYang.,Song Bo.,Liu LingLing.,Zhang XiuFang.,...&Gong YanDao.(2010).Endogenously generated amyloid beta increases membrane fluidity in neural 2a cells..
MLA	Niu Ying,et al."Endogenously generated amyloid beta increases membrane fluidity in neural 2a cells".(2010).

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