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	The effect of 3-hydroxybutyrate methyl ester on learning and memory in mice
	Zou, Xiang-Hui ; Li, Hong-Ming ; Wang, Sheng ; Leski, Michael ; Yao, Yong-Chao ; Yang, Xiao-Di ; Huang, Qing-Jun ; Chen, Guo-Qiang
	2010-10-12 ; 2010-10-12
关键词	PHB 3-Hydroxybutyrate methyl ester Learning and memory PUMA-G Connexin Gap junctional intercellular communication JUNCTIONAL INTERCELLULAR COMMUNICATION ACETYL-L-CARNITINE PARKINSONS-DISEASE NICOTINIC-ACID HIPPOCAMPAL-NEURONS CELL-GROWTH PUMA-G INHIBITION RECEPTOR POLYHYDROXYALKANOATES Engineering, Biomedical Materials Science, Biomaterials
中文摘要	Learning and memory requires energy-demanding cellular processes and call be enhanced when the brain is Supplemented with metabolic substrates. In this Study, we found that neuroglial cell metabolic activity was significantly elevated when cultured in the presence of polyhydroxybutyrate (PHB) degradation product 3-hydroxybutyrate (3-HB) and derivatives. We demonstrated that the receptor for 3-HB, namely, protein upregulated in macrophages by IFN-gamma (PUMA-G), was expressed in brain and upregulated ill mice treated with 3-hydroxybutyrate methyl ester (3-HBME). We also affirmed increased expression of connexin 36 protein and phosphorylated ERK2 (extracellular signal-regulated kinase 2) in brain tissues following 3-HBME treatment, although these differences were not statistically significant. Mice treated with 3-HBME performed significantly (p < 0.05) better in the Morris water maze than either the negative controls (no treatment) or positive controls (acetyl-1-carnitine treatment). Moreover, we found that 3-HBME enhanced gap junctional intercellular communication between neurons. Thus, 3-HB and derivatives enhance learning and memory, possibly through a signaling pathway requiring PUMA-G that increases protein synthesis and gap junctional intercellular communication. (C) 2008 Elsevier Ltd. All rights reserved.
语种	英语 ; 英语
出版者	ELSEVIER SCI LTD ; OXFORD ; THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
内容类型	期刊论文
源URL	[http://hdl.handle.net/123456789/81841]
专题	清华大学
推荐引用方式 GB/T 7714	Zou, Xiang-Hui,Li, Hong-Ming,Wang, Sheng,et al. The effect of 3-hydroxybutyrate methyl ester on learning and memory in mice[J],2010, 2010.
APA	Zou, Xiang-Hui.,Li, Hong-Ming.,Wang, Sheng.,Leski, Michael.,Yao, Yong-Chao.,...&Chen, Guo-Qiang.(2010).The effect of 3-hydroxybutyrate methyl ester on learning and memory in mice..
MLA	Zou, Xiang-Hui,et al."The effect of 3-hydroxybutyrate methyl ester on learning and memory in mice".(2010).

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