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	Therapeutic potential of lipase inhibitor orlistat in Alzheimer's disease
	Du, Jing ; Wang, Zhao
	2010-10-12 ; 2010-10-12
关键词	VASCULAR RISK-FACTORS ACTIVE-SITE SERINE LIPOPROTEIN-LIPASE PANCREATIC LIPASE SERUM-LIPIDS FAT INTAKE DEMENTIA MIDLIFE TETRAHYDROLIPSTATIN CHOLESTEROL Medicine, Research & Experimental
中文摘要	Emerging evidences indicate that elevated cholesterol and triglyceride levels precede Alzheimer's disease (AD) pathology. High caloric intake based on saturated fat raises hyperlipidaemia and also promotes AD pathology. As a result, strategy that limits the absorption of dietary fat and attenuates hyperlipidemia could be a useful medication for protective treatment of AD. As an active site-directed inhibitor of digestive lipases, orlistat effectively reduces dietary fat absorption and decreases total cholesterol and triglyceride levels in plasma. Orlistat also potently inhibits lipoprotein lipase, monoacylglycerol lipase and diacylglycerol lipase, which are also involved in AD causation. Taken together, orlistat inhibits lipases activities, thereby reduces dietary fat intake and ameliorates hyperlipidemia, which indicates a therapeutic potential of orlistat in protecting against AD pathology. (C) 2009 Elsevier Ltd. All rights reserved.
语种	英语 ; 英语
出版者	CHURCHILL LIVINGSTONE ; EDINBURGH ; JOURNAL PRODUCTION DEPT, ROBERT STEVENSON HOUSE, 1-3 BAXTERS PLACE, LEITH WALK, EDINBURGH EH1 3AF, MIDLOTHIAN, SCOTLAND
内容类型	期刊论文
源URL	[http://hdl.handle.net/123456789/81818]
专题	清华大学
推荐引用方式 GB/T 7714	Du, Jing,Wang, Zhao. Therapeutic potential of lipase inhibitor orlistat in Alzheimer's disease[J],2010, 2010.
APA	Du, Jing,&Wang, Zhao.(2010).Therapeutic potential of lipase inhibitor orlistat in Alzheimer's disease..
MLA	Du, Jing,et al."Therapeutic potential of lipase inhibitor orlistat in Alzheimer's disease".(2010).

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