| The leaf extract of Siberian Crabapple (Malus baccata (Linn.) Borkh) contains potential fatty acid synthase inhibitors | |
| Wei, Xiang ; Zhao, Ran ; Sun, Ying-Hui ; Cong, Jian-Ping ; Meng, Fan-Guo ; Zhou, Hai-Meng | |
| 2010-10-12 ; 2010-10-12 | |
| 关键词 | Siberian Crabapple leave extract fatty acid synthase (FAS) inhibitor TEA EPIGALLOCATECHIN GALLATE FOOD-INTAKE GREEN TEA ENERGY HOMEOSTASIS BODY-WEIGHT OBESITY SIGNALS Biochemistry & Molecular Biology Chemistry, Medicinal |
| 中文摘要 | The present work focused on the kinetics of the inhibitory effects of the leaf extract of Siberian Crabapple, named Shan jingzi in China, on chicken liver fatty acid synthase. The results showed that this extract had much stronger inhibitory ability on fatty acid synthase than that from green teas described in many previous reports. The inhibitory ability of this extract is closely related to the extracting solvent, and the time of extraction was also an important influencing factor. The inhibitory types of this extract on diffeerent substrates of chicken liver fatty acid synthase, acetyl-CoA, malonyl-CoA and NADPH, were found to be noncompetitive, uncompetitive and mixed, respectively. The studies here shed a new light on the exploration for inhibitors of fatty acid synthase. |
| 语种 | 英语 ; 英语 |
| 出版者 | TAYLOR & FRANCIS LTD ; ABINGDON ; 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND |
| 内容类型 | 期刊论文 |
| 源URL | [http://hdl.handle.net/123456789/81807]  |
| 专题 | 清华大学 |
| 推荐引用方式 GB/T 7714 | Wei, Xiang,Zhao, Ran,Sun, Ying-Hui,et al. The leaf extract of Siberian Crabapple (Malus baccata (Linn.) Borkh) contains potential fatty acid synthase inhibitors[J],2010, 2010. |
| APA | Wei, Xiang,Zhao, Ran,Sun, Ying-Hui,Cong, Jian-Ping,Meng, Fan-Guo,&Zhou, Hai-Meng.(2010).The leaf extract of Siberian Crabapple (Malus baccata (Linn.) Borkh) contains potential fatty acid synthase inhibitors.. |
| MLA | Wei, Xiang,et al."The leaf extract of Siberian Crabapple (Malus baccata (Linn.) Borkh) contains potential fatty acid synthase inhibitors".(2010). |
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